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chemodenervation

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chemodenervation 
A technique in which a pharmacologic compound (e.g. atropine, botulinum toxin) is used to paralyse a muscle or group of muscles. This technique is most often used in the treatment of certain forms of strabismus as well as blepharospasm.


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Although BTA is often thought of as a cosmetic drug, when injected into a spastic muscle, it works to block the release of acetylcholine and effectively causes a chemodenervation of the target muscles without adversely affecting the antagonist muscles (Koman, Smith, & Balkrishnan, 2003).
Botox is a chemodenervation agent that weakens the target muscle by preventing acetylcholine release at the motor end plate.
 
 
 
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