Chemodenervation | definition of chemodenervation by Medical dictionary
A technique in which a pharmacologic compound (e.g. atropine, botulinum toxin) is used to paralyse a muscle or group of muscles. This technique is most often used in the treatment of certain forms of strabismus as well as blepharospasm.
References in periodicals archive
Ultrasound-guided chemodenervation procedures; text and atlas.
Standard techniques to localize muscles or nerves have limitations for physicians performing chemodenervation procedures.
The two major invasive interventions for managing spasticity are administration of intravenous and intrathecal medication (discussed above) and chemodenervation
Targeted injection leads to chemodenervation
and targeted muscle relaxation.
Botox is a chemodenervation
agent that weakens the target muscle by preventing acetylcholine release at the motor end plate.
These injections produce a dose-dependent chemodenervation