chemical mediator

chemical mediator

a neurotransmitter chemical, such as acetylcholine.

chemical mediator

A nonspecific term for a chemical agent which carries out a process or reaction.

Chemical mediator is often used interchangeably with neurotransmitter—when possible, the latter term should be used as it confers specificity.
References in periodicals archive ?
So therefore we believe that the gastrointestinal absorption of disodium cromoglycate in guinea-pig can be different from that in human, and at the low blood level of disodium cromoglycate may inhibit the chemical mediator release from bronchial mast cells and the activation of leukocytes (Svendsen et al.
A new study demonstrates that a chemical mediator in the blood that influences immune cell migration also plays a key role in maintaining the balance between the build-up and breakdown of bones in the body.
Localized mast cells in affected tissues produce histamine, a chemical mediator that dilates blood vessels at the site of injury, producing redness and heat.
For years, antihistamines--so called because they work to block the release of the chemical mediator histamine, thought to be a primary mediator in sinus allergies--and decongestants were considered to be first-line treatment.
About Pirfenidone Pirfenidone is an orally active, anti-fibrotic agent that inhibits the synthesis of TGF-beta, a chemical mediator that controls many cell functions including proliferation and differentiation, and plays a key role in fibrosis.
This is important because IgE is a key chemical mediator in allergic reactions.
Pirfenidone is an orally active, small molecule drug that inhibits the synthesis of TGF-beta, a chemical mediator that controls many cell functions including proliferation and differentiation, and plays a key role in fibrosis.
Rigel's syk kinase inhibitors are designed to bind to syk in mast cells and interrupt the signal from the IgE receptor, thus preventing cellular activation and subsequent chemical mediator release, and potentially blocking an allergic response in allergic asthma.
R112 binds to an intracellular target (syk, a kinase that regulates IgE receptor signaling) in mast cells and interrupts the signal from the IgE receptor, thus preventing cellular activation and subsequent chemical mediator release.
R112 enters mast cells, binds to an intracellular target and interrupts the signal from the IgE receptor, thus preventing downstream signaling and subsequent chemical mediator release.
Rigel's R112 compound enters mast cells, binds to an intracellular target and interrupts the signal from the IgE receptor, thus preventing downstream signaling and subsequent chemical mediator release.
However, unlike common allergy and asthma drugs that block only a single chemical mediator, Syk inhibitors block the major IgE dependent pathways in mast cells that trigger an allergic attack, potentially making Syk inhibitors more effective and comprehensive drugs.