chemical genomics

chemical genomics

use of organic chemicals, commonly referred to as "small molecules," to study the functions of the cell at the genome level.
Synonym(s): chemogenomics
References in periodicals archive ?
Li joined OMRFs Functional and Chemical Genomics Program in 2017 from Northwestern University in Chicago.
Our findings provide important new insights into the mechanism of action by which cyclodextrin reduces cholesterol buildup in NPC1 cells and eventually restores a balance, said Marugan, who is acting branch chief of the NCATS Chemical Genomics Center.
In the first phase of testing at the NIH Chemical Genomics Center, scientists screened up to 2,800 compounds with about 70 high-throughput assays.
Using high-throughput chemical screening at LSI's Center for Chemical Genomics to search for compounds that inhibit IKKE and TBK1, the researchers hit upon an approved off-patent drug: amlexanox.
NIH partners include the National Toxicology Program (NTP), administered by the National Institute of Environmental Health Sciences (NIEHS), and the NIH Chemical Genomics Center (NCGC), part of the NIH Center for Translational Therapeutics (NCTT), housed at the National Human Genome Research Institute (NHGRI).
The NIH now encourages academic researchers to take their targets to the assay stage and beyond, providing high-throughput screening (HTS) assistance from the NIH Chemical Genomics Center.
Researchers in computational biology, chemoinformatics and chemometrics, computer science, and other scientific and computer-related fields in Europe, the US, and Japan discuss methods for computing similarity in chemical spaces; methodologies that combine graph mining and machine learning techniques; important elements of chemoinformatics, including statistical and Bayesian techniques and partial least square methods; the integration of ideas from fields like chemoinformatics, bioinformatics, and systems biology for the development of methods to solving chemical problems; and machine learning for chemical genomics that requires useful computational approaches to investigate the relationship between chemical space of possible compounds and genomic space of possible genes or proteins.
Novartis Vaccines & Diagnostics, Abbott Laboratories, Genzyme Transplant and Oncology, LIMR Chemical Genomics Center, the University City Science Center, Crown Bioscience, Bay City Capital, and Safeguard Scientifics, to name just a few.
Two NIH institutes have formed a collaboration with the EPA to use the NIH Chemical Genomics Center's (NCGC) high-speed, automated screening robots to test suspected toxic compounds using cells and isolated molecular targets instead of laboratory animals.
Human cells of interest, such as liver or skin cells, can be placed in each of 1,536 tiny wells in a single dish, says NIH Chemical Genomics Center Director Christopher Austin.
These deals represent an important strategic step for VASTox as they strengthen and diversify its drug discovery and development pipeline through the addition of two clinical and two pre-clinical programmes in neurological and ophthalmic diseases, which will provide increased near-term opportunities for high-value licensing and partnership deals; enhance its scientific expertise and capabilities in zebrafish chemical genomics and carbohydrate chemistry; and boost its scientific infrastructure through the acquisition of two high-tech laboratory facilities in Cambridge and Reading.
and the National Institutes of Health (NIH) have entered into an agreement in which the latter will access Kalypsys' proprietary technologies as a key enabler of research at the recently created NIH chemical genomics center.
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