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carcinogenesis |
Also found in: Dictionary/thesaurus, Encyclopedia, Wikipedia, Hutchinson | 0.01 sec. |
carcinogenesis [kär′sinəjen′əsis] the process of initiating and promoting cancer. Compare malignant transformation, oncogenesis, sarcomagenesis, tumorigenesis. carcinogenesis production of cancer. biological carcinogenesis viruses and some parasites are capable of initiating neoplasia. See viral oncogenesis, Spirocercalupi. chemical carcinogenesis numerous chemicals have been identified as carcinogenic. physical carcinogenesis includes ultraviolet radiation, ionizing radiation and asbestos. carcinogenesis Transformation, tumourigenesis Oncology A series of genotypic and phenotypic changes that result in a cell being identified as malignant by virtue of its metastatic potential. See Cancerization, Chemical carcinogenesis, Inducer, One-hit/two-hit model, Proto-oncogenes, Tumor promoter, Tumor suppressor. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Mice deficient in COX-2 develop 75% fewer tumors than their wild type littermates when subjected to a 9,10-dimethylbenz[a]anthracene/12-O-tetradecanoylphorbol-13-acetate two-stage chemical carcinogenesis protocol (Tiano et al. We know these compounds can probably cause cancer in humans," says Elizabeth Snyderwine, Chief of the Chemical Carcinogenesis Section at the National Cancer Institute (NCI) in Bethesda, Maryland. He chaired a number of federal committees and task forces, including the development and implementation of the Technology Transfer Act of 1986 and the White House Task Force on Chemical Carcinogenesis. |
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