chemical carcinogenesis


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chemical carcinogenesis

The induction of malignancy by a known or putative chemical carcinogen, which can be occupational (e.g., aromatic amines, arsenic, benzene, cadmium, chromium ores, soots, tars, vinyl chloride), environmental (e.g., aflatoxin, asbestos, tobacco) or iatrogenic (e.g., alkylating agents, anabolic steroids, phenacetin).
 
Pathogenesis
Initiation of the carcinogenic cascade occurs when an electrophilically reactive chemical (initiator) or, more often, one or more of its metabolites interacts with DNA, and repair of the damaged DNA is unsuccessful; this is followed by a sequence of events known as tumour promotion.

carcinogenesis

production of cancer.

biological carcinogenesis
viruses and some parasites are capable of initiating neoplasia. See viral oncogenesis, Spirocercalupi.
chemical carcinogenesis
numerous chemicals have been identified as carcinogenic.
physical carcinogenesis
includes ultraviolet radiation, ionizing radiation and asbestos.
References in periodicals archive ?
Anti-tumor principles from Nigella sativa and saffron (Crocus sativus) on chemical carcinogenesis in mice.
He chaired a number of federal committees and task forces, including the development and implementation of the Technology Transfer Act of 1986 and the White House Task Force on Chemical Carcinogenesis.
Although assumed, proof of the direct emergence of epithelial CSCs from an NSC population is not available, and the identity of the cells that acquire the molecular lesions initiating chemical carcinogenesis remains undefined (Perez-Losada and Balmain 2003).
In Chapter six the author missed a good opportunity to discuss biochemical principles in more detail such processes like mutagenesis, chemical carcinogenesis, teratogenesis and immunotoxicity, which are fundamental in toxicology.
They were instead designed to assist epidemiologists in making inductive inferences about the causal relationship of observed associations or, in the language of chemical carcinogenesis, as an aid in addressing the question, "Does a chemical exposure cause cancer?
Understanding what modulates changes in DNA methylation during malignant transformation is a key issue in chemical carcinogenesis.
Mice deficient in COX-2 develop 75% fewer tumors than their wild type littermates when subjected to a 9,10-dimethylbenz[a]anthracene/12-O-tetradecanoylphorbol-13-acetate two-stage chemical carcinogenesis protocol (Tiano et al.
Indeed, gestation is a period of high sensitivity to chemical carcinogenesis in general in both rodents and probably humans (Anderson et al.
A critical review of experiments in chemical carcinogenesis using newborn animals.
In 1984 the NTP Board of Scientific Counselor's Ad Hoc Panel on Chemical Carcinogenesis Testing and Evaluation report recommended that the NTP "establish a goal of better understanding mechanisms by developing a battery of short-term tests that measures the widest possible number of end points (including promotion, transformation, and chemical interaction with oncogenes)" (NTP 1984).
Selikoff Clinical Center for Occupational and Environmental Medicine); Lorenzo Tomatis, then chief of the Unit of Chemical Carcinogenesis, International Agency for Research on Cancer (later director of IARC); and Arthur Upton, then director of the National Cancer Institute.