Mice suffering from liver cancers were given either homoeopathic Carcinosin 200C, or a combination of Carcinosin 200C and Chelidonium
200C over a period of 120 days.
At the same time, selected groups of these mice were given either homoeopathic Chelidonium in 30C or 200C potencies or a placebo control.
Both potencies of Chelidonium provided a significant protective effect against the formation of liver cancers and favourably modulated some of the haematological markers normally associated with hepatotoxicity.
This study demonstrates that chelidonine and an alkaloid extract from Chelidonium majus, which contains protoberberine and benzoiciphenanthridine alkaloids, has the ability to overcome MDR of different cancer cell lines through interaction with ABC-transporters, CYP3A4 and GST, by induction of apoptosis, and cytotoxic effects.
According to the description of the European Pharmacopoeia to herbal substance, Chelidonium extract has a minimum of 0.
However, the clinical data concerning Ukrain cannot be applied to the alkaloids of C majus or Chelidonium extracts because Ukrain has been modified by conjugation of one molecule of thiophosphoric acid to three molecules of chelidonine.
Correlation of the cytotoxic activity of four different alkaloids, from Chelidonium
majus (greater celandine), with their DNA intercalating properties and ability to induce breaks in the DNA of NK/Ly murine lymphoma cells.
Hydroxycinnamic acid derivatives, caffeoyl malic acid and new caffeoylaldonic acid esters from Chelidonium
The yohimbine rich bark of Corynanthe yohimbe, has been employed for centuries as an aphrodisiac (Johanson and Diamond, 1968) whilst Chelidonium
majus, Heracleum sphondylium and Satureja montana have been formulated into topical preparations by the European community for vaginal douches to increase sexual desire in women (Messegne, 1973).
Psoralea corylifolia (Leguminosae) and Chelidonium majus (Papaveraceae) are used in folk medicine for the treatment of breast, colon, ovarian, testicular and stomach cancer (Duke, 1985).
50] could not be determined for Atropa belladonna, Plantago major and Chelidonium majus as their extracts did not elicit 50% inhibition (Fig.
50] tested ([mu]g/ml) + Psoralea corylifolia (2) Fruit 22 [+ or -] 6 (Leguminosae) Dianthus sinensis (1) Whole plant 111 [+ or -] 19 (Caryophyllaceae) Phytolacca polyandra (1) Whole plant 129 [+ or -] 13 (Phytolaccaceae) Sophora flavescens Ait (2) Root 134 [+ or -] 17 (Leguminosae) Cephalotaxus fortunei (2) Branch 134 [+ or -] 27 (Cephalotaxaceae) Polygonatum odoratum (1) Root 142 [+ or -] 11 (Convallariaceae) Coptis chinensis French (2) Whole plant 412 [+ or -] 32 (Ranunculaceae) Terminalia chebula Retz (2) Fruit 201 [+ or -] 51 (Combretaceae) Atropa belladonna (1) Fruit N/D (Solanaceae) Chelidonium majus (1) Whole plant N/D (Papaveraceae) Plantago major (1) Root N/D (Plantaginaceae) Plants orginated from: (1)National Botanic Gardens, Glasnevin, Dublin (2)Taiwan.