The plant contains, as major constituents, isoquinoline alkaloids (such as sanguinarine, chelidonine
, chelerythrine, berberine, protopine and coptisine), flavonoids, and phenolic acids.
Purpose: In this study the effects of naturally occurring homochelidonine in comparison to chelidonine on cell cycle progression and cell death in leukemic T-cells with different p53 status are described.
Results: We found that homochelidonine and chelidonine displayed significant cytotoxicity in examined blood cancer cells with the exception of HEL 92.
Ukrain comprises one molecule thiophosphoric acid conjugated to three molecules of chelidonine [6,7].
The Ukrain is a synthetic derivative of thiotepa and the chelidonine, a main component of the greater celandine (Chelidonium majus L.
Morphine-like properties associated with chelidonine
and homochlidonine have been found in the North American species of poppy, Sanguinaria canadensis.
Sanguinarine and chelerythrine are the most prominent alkaloids obtained from roots while coptisine, chelidonine and berberine are usually obtained from the aerial parts.
Ukrain[TM], a purported anticancer drug, has been described as a semi-synthetic Chelidonium majus alkaloid derivative, consisting of three chelidonine molecules combined to thiophosphoric acid (thiotepa).
IQA papaverine, sanguinarine, protoverine, and chelidonine are GI tract irritants and CNS stimulants (Ribeiro and Rodriguez de Lores Arnaiz 2000; Liu et al.
Six cularine alkaloids; cularicine, O-methyl-cularicine, celtisine, cularidine, cularine and celtine, three isocularine alkaloids; sarcophylline, sarcocapnine and sarcocapnidine, and five non-cularine alkaloids; glaucine, protopine, ribasine, dihydrosanguinarine and chelidonine, were identified from the genus Sarcocapnos (Fumariaceae): S.
6% of alkaloids specified, calculated as chelidonine
This study demonstrates that chelidonine
and an alkaloid extract from Chelidonium majus, which contains protoberberine and benzoiciphenanthridine alkaloids, has the ability to overcome MDR of different cancer cell lines through interaction with ABC-transporters, CYP3A4 and GST, by induction of apoptosis, and cytotoxic effects.