chelate

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chelate

 [ke´lāt]
1. to combine with a metal in complexes in which the metal is part of a ring.
2. by extension, a chemical compound in which a metallic ion is sequestered and firmly bound into a ring within the chelating molecule. Chelates are used in chemotherapy of metal poisoning.

che·late

(kē'lāt),
1. To effect chelation.
2. Pertaining to chelation.
3. A complex formed through chelation.

chelate

/che·late/ (ke´lāt)
1. to combine with a metal in complexes in which the metal is part of a ring.
2. by extension, a chemical compound in which a metallic ion is sequestered and firmly bound into a ring within the chelating molecules. Chelates are used in chemotherapy of metal poisoning.

chelate

(kē′lāt′)
adj. Zoology
Having chelae or resembling a chela.
n. Chemistry
A chemical compound in the form of a heterocyclic ring, containing a metal ion attached by coordinate bonds to at least two nonmetal ions.
tr.v. che·lated, che·lating, che·lates
1. Chemistry To combine (a metal ion) with a chemical compound to form a ring.
2. Medicine To remove (a heavy metal, such as lead or mercury) from the bloodstream by means of a chelate, such as EDTA.

che′lat·a·ble adj.
che·la′tion n.
che′la′tor n.

chelate

[kē′lāt]
Etymology: Gk, chele, claw
1 v, to form a bond, thus creating a ringlike complex. An example is the interaction of a metal ion and two or more polar groups of a single molecule.
2 n, (in medicine) any coordination compound composed of a central metal ion and an organic molecule with multiple bonds arranged in ring formations, used especially in chemotherapeutic treatments for metal poisoning.
3 adj, pertaining to chelation.

che·late

(kē'lāt)
1. To effect chelation.
2. Pertaining to chelation.
3. A complex formed through chelation.

chelate

  1. possessing claws or pincer-like appendages.
  2. to combine with a metal ion to form a stable compound.

Chelate

A chemical that binds to heavy metals in the blood, thereby helping the body to excrete them in urine.
Mentioned in: Nephrotoxic Injury

chelate

to combine with a metal in complexes in which the metal is part of a ring; by extension, a chemical compound in which a metallic ion is sequestered and firmly bound into a ring within the chelating molecule. Chelates are used in treatment of metal poisoning.
References in periodicals archive ?
Accumulation and extrusion of permeant Ca2+ chelators in attenuation of synaptic transmission at hippocampal CA1 neurons.
Further research would be needed to find chelators that are food-safe.
However, most known chelators can't cross the blood-brain barrier, the barricade of cells that separates brain tissue from circulating blood, protecting the brain from harmful substances in the bloodstream.
Bidentate chelators typically form 3:1 complexes with the normally six coordinate ferric ion.
A middle-aged male will typically have a higher load of stored iron and calcium and may benefit from a higher loading dose of mineral chelators, to speed along their removal, followed by a lower dose for long-term maintenance," says Sardi.
When it's combined with sodium alginate, from seaweed, it becomes a strong chelator of all heavy metals--including mercury.
The National Institute on Health (NIH)-funded study was undertaken to assess PectaSol MCP as a safe and effective oral chelator of lead, mercury, arsenic and other toxic metals from the human body.
Using one of the conventional, nonspecific chelators to respond to a dirty-bomb attack in an urban setting would be like throwing away the expensive compound, Smith says.
A synthetic model chelator, functionally similar to the natural chelators produced by G.
While chelators are not new, during recent years some of the chemical companies have been aggressively marketing synthetic chelates.
They are generally used with phosphite chelators and epoxy secondary plasticizers.
In the opposite mode, chelators cause a chemical reaction that changes temporary hardness into permanent hardness; the salts that react with the chelator join the solution.