chelate

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chelate

 [ke´lāt]
1. to combine with a metal in complexes in which the metal is part of a ring.
2. by extension, a chemical compound in which a metallic ion is sequestered and firmly bound into a ring within the chelating molecule. Chelates are used in chemotherapy of metal poisoning.

che·late

(kē'lāt),
1. To effect chelation.
2. Pertaining to chelation.
3. A complex formed through chelation.

chelate

/che·late/ (ke´lāt)
1. to combine with a metal in complexes in which the metal is part of a ring.
2. by extension, a chemical compound in which a metallic ion is sequestered and firmly bound into a ring within the chelating molecules. Chelates are used in chemotherapy of metal poisoning.

chelate

(kē′lāt′)
adj. Zoology
Having chelae or resembling a chela.
n. Chemistry
A chemical compound in the form of a heterocyclic ring, containing a metal ion attached by coordinate bonds to at least two nonmetal ions.
tr.v. che·lated, che·lating, che·lates
1. Chemistry To combine (a metal ion) with a chemical compound to form a ring.
2. Medicine To remove (a heavy metal, such as lead or mercury) from the bloodstream by means of a chelate, such as EDTA.

che′lat·a·ble adj.
che·la′tion n.
che′la′tor n.

chelate

[kē′lāt]
Etymology: Gk, chele, claw
1 v, to form a bond, thus creating a ringlike complex. An example is the interaction of a metal ion and two or more polar groups of a single molecule.
2 n, (in medicine) any coordination compound composed of a central metal ion and an organic molecule with multiple bonds arranged in ring formations, used especially in chemotherapeutic treatments for metal poisoning.
3 adj, pertaining to chelation.

che·late

(kē'lāt)
1. To effect chelation.
2. Pertaining to chelation.
3. A complex formed through chelation.

chelate

  1. possessing claws or pincer-like appendages.
  2. to combine with a metal ion to form a stable compound.

Chelate

A chemical that binds to heavy metals in the blood, thereby helping the body to excrete them in urine.
Mentioned in: Nephrotoxic Injury

chelate

to combine with a metal in complexes in which the metal is part of a ring; by extension, a chemical compound in which a metallic ion is sequestered and firmly bound into a ring within the chelating molecule. Chelates are used in treatment of metal poisoning.
References in periodicals archive ?
It thus makes sense to 'cleanse' the digestive tract prior to chelation, because a properly prepared intestinal tract will allow the oral chelator to pass relatively unbound through the mucous membranes into the blood stream from where it is transported to organ systems in need of detoxification.
In this study, we hypothesized that in addition to the well-investigated molecular mechanisms for iron and the action of an iron chelator, DFO, their activity may be associated with regulating intracellular calcium.
The results obtained showed that the hexane extract is a good chelator.
It is reported in some recent studies that a naturally present flavolignan and Silybin extracted from the fruits of silibiummarianum possess some antioxidant and radical scavenging abilities that works as an iron chelator (Borsari et al.
Using the calcium chelator BAPTA-AM and several different drugs, aged animals were tested before and after treatment with the agent and compared with young animals.
7 months, there were 2 deaths unrelated to chelators (hepatocellular carcinoma in a patient with hepatitis C and cardiovascular related death in the other).
High efficacy and compliance, low adverse effects and cost, providing 24hour drug coverage and reduction of gap free iron chelators should be added to the aforementioned items.
begins with a foam concoction of strong acids, reductants, and chelators that remove contamination.
Both contain nutrients known as iron chelators which bind tightly to the