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chelate |
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chelate /che·late/ (ke´lāt) 1. to combine with a metal in complexes in which the metal is part of a ring. 2. by extension, a chemical compound in which a metallic ion is sequestered and firmly bound into a ring within the chelating molecules. Chelates are used in chemotherapy of metal poisoning.
Chelate A chemical that binds to heavy metals in the blood, thereby helping the body to excrete them in urine. Mentioned in: Nephrotoxic Injury chelate [kē′lāt] Etymology: Gk, chele, claw 1 v, to form a bond, thus creating a ringlike complex. An example is the interaction of a metal ion and two or more polar groups of a single molecule. 2 n, (in medicine) any coordination compound composed of a central metal ion and an organic molecule with multiple bonds arranged in ring formations, used especially in chemotherapeutic treatments for metal poisoning. 3 adj, pertaining to chelation. chelate to combine with a metal in complexes in which the metal is part of a ring; by extension, a chemical compound in which a metallic ion is sequestered and firmly bound into a ring within the chelating molecule. Chelates are used in treatment of metal poisoning. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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It chemically captures, or chelates, excess iron but must be given intravenously or by injection. The effect of succimer treatment to significantly increase the excretion of Pb in the urine is consistent with the action of this drug to form aqueous soluble chelates with Pb (12), as well as with a large body of clinical and laboratory evidence showing increased urinary excretion of Pb with treatment (1,17,25,26). Generally, chelates improve the absorption of minerals by about five or ten percent, but they cost five times as much. |
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