chelate

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chelate

 [ke´lāt]
1. to combine with a metal in complexes in which the metal is part of a ring.
2. by extension, a chemical compound in which a metallic ion is sequestered and firmly bound into a ring within the chelating molecule. Chelates are used in chemotherapy of metal poisoning.

che·late

(kē'lāt),
1. To effect chelation.
2. Pertaining to chelation.
3. A complex formed through chelation.

chelate

/che·late/ (ke´lāt)
1. to combine with a metal in complexes in which the metal is part of a ring.
2. by extension, a chemical compound in which a metallic ion is sequestered and firmly bound into a ring within the chelating molecules. Chelates are used in chemotherapy of metal poisoning.

chelate

(kē′lāt′)
adj. Zoology
Having chelae or resembling a chela.
n. Chemistry
A chemical compound in the form of a heterocyclic ring, containing a metal ion attached by coordinate bonds to at least two nonmetal ions.
tr.v. che·lated, che·lating, che·lates
1. Chemistry To combine (a metal ion) with a chemical compound to form a ring.
2. Medicine To remove (a heavy metal, such as lead or mercury) from the bloodstream by means of a chelate, such as EDTA.

che′lat·a·ble adj.
che·la′tion n.
che′la′tor n.

chelate

[kē′lāt]
Etymology: Gk, chele, claw
1 v, to form a bond, thus creating a ringlike complex. An example is the interaction of a metal ion and two or more polar groups of a single molecule.
2 n, (in medicine) any coordination compound composed of a central metal ion and an organic molecule with multiple bonds arranged in ring formations, used especially in chemotherapeutic treatments for metal poisoning.
3 adj, pertaining to chelation.

che·late

(kē'lāt)
1. To effect chelation.
2. Pertaining to chelation.
3. A complex formed through chelation.

chelate

  1. possessing claws or pincer-like appendages.
  2. to combine with a metal ion to form a stable compound.

Chelate

A chemical that binds to heavy metals in the blood, thereby helping the body to excrete them in urine.
Mentioned in: Nephrotoxic Injury

chelate

to combine with a metal in complexes in which the metal is part of a ring; by extension, a chemical compound in which a metallic ion is sequestered and firmly bound into a ring within the chelating molecule. Chelates are used in treatment of metal poisoning.
References in periodicals archive ?
Chelatable lead in relation to lead in bone and ALAD genotype.
Predictors of DMSA chelatable lead, tibial lead, and blood lead in 802 Korean lead workers.
Predictors of dimercaptosuccinic acid chelatable lead and tibial lead in former organolead manufacturing workers.
This finding appears to be in keeping with studies indicating that ascorbic acid may in some manner increase intracellular chelatable iron by facilitating mobilization of iron from the ferritin compartment (4).
Alternatively, perturbations of serum ferritin concentrations by effects of iron overload, of inflammation, and of hepatocellular dysfunction may have masked a small effect due to changes in chelatable intracellular iron (20-22).
Children ALAD BLL, HB 2004 Abbreviations: BLL, blood lead level; BUN, blood urea nitrogen; CBL, calcaneus bone lead; DBP, diastolic blood pressure; DMSA, DMSA- chelatable lead; HB, hemoglobin; PBL, patella bone lead; SBP, systolic blood pressure; SC, serum creatinine; TBL, tibia bone lead; ZPP, zinc protoporphyrin.
The estimated concentration of iron bound to the LMW ligands (the so-called chelatable iron) is 1-10 [micro]M in rodent and human cells (Petrat et al.
The chelatable iron pool in living cells: a methodically defined quantity.