CHAT

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CHAT

A gene on chromosome 10q11.2 that encodes choline acetyltransferase, which binds acetylCoA to choline, controlling acetylcholine production at the synapses of the autonomic nervous system, muscle and the sympathetic nervous system.

Molecular pathology
Polymorphisms of CHAT have been associated with choline acetyltransferase depletion in Alzheimer’s disease and cognitive impairment; CHAT mutations are associated with congenital myasthenic syndrome associated with episodic apnoea.
References in classic literature ?
Seated on the poop, Ned Land and I were chatting of one thing and another as we looked at this mysterious sea, whose great depths had up to this time been inaccessible to the eye of man.
Mistress of deceit, however, she appeared perfectly unconcerned, and after chatting on indifferent subjects for a short time, said to me, "I find from Wilson that we are going to lose Mr.
Just as he was falling asleep, he heard two men passing by, chatting together; and one said to the other, 'How can we rob that rich parson's house of his silver and gold?
But Diana and her small fry, the Echo Lodge people and the Allans, had stayed to help the two old ladies over the loneliness of the first evening; and they contrived to have a quietly pleasant little supper time, sitting long around the table and chatting over all the details of the day.
As his wife grew older, she became even a more cheerful and light-hearted little creature; and it was a common saying among their friends, that it was impossible to say which looked the happier, Tim as he sat calmly smiling in his elbow-chair on one side of the fire, or his brisk little wife chatting and laughing, and constantly bustling in and out of hers, on the other.
Sergey Ivanovitch liked to stretch himself on the grass in the sun, and to lie so, basking and chatting lazily.