CHAT

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CHAT

A gene on chromosome 10q11.2 that encodes choline acetyltransferase, which binds acetylCoA to choline, controlling acetylcholine production at the synapses of the autonomic nervous system, muscle and the sympathetic nervous system.

Molecular pathology
Polymorphisms of CHAT have been associated with choline acetyltransferase depletion in Alzheimer’s disease and cognitive impairment; CHAT mutations are associated with congenital myasthenic syndrome associated with episodic apnoea.
References in classic literature ?
He had not chatted ten minutes with the people of the tavern before he learned that a woman had come there alone about eleven o'clock the night before, had engaged a chamber, had sent for the master of the hotel, and told him she desired to remain some time in the neighborhood.
Advancing with an alert step, and free and easy air, he threw the buck on the ground, and, without waiting for an invitation, seated himself at their mess, helped himself without ceremony, and chatted to the right and left in the liveliest and most unembarrassed manner.
I met George Morton at the door, and chatted with him for several minutes.
The visitor chatted carelessly for a few moments about the gossip of the city and the university, and then took up another topic.
The half hour was chatted away pleasantly enough; and she was not at all surprised at the end of it, to have their walking party joined by both the Miss Musgroves, at Mary's particular invitation.

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