chaperones


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chaperones

Chaperonins, intracellular proteins that assist in the correct folding of other proteins by means of hydrophobic surfaces that recognize and bind to exposed hydrophobic surfaces on misfolded proteins. Chaperones also assist proteins to arrive at the sites in the cell where they carries out their function. Intracellular proteins with abnormal configurations interact abnormally with other molecules, and many disease processes relate to misfolded proteins. Misfolding of proteins that are regulators of growth and differentiation and contribute to ageing and many diseases. It may, for instance, may be an important factor in the causation of cancers. Protein misfolding may be a factor in as many as half of all diseases. Increasing understanding of this phenomenon may lead to new and important therapies.
References in periodicals archive ?
The hospital's chaperone policy required either a family member or another professional to chaperone any intimate examination.
Meanwhile, Yeshivah of Flatbush students, as well as the group's chaperones, insist that the Southwest Airlines crew was merely overreacting to the situation, CNN reports.
Giedroc and his coworkers describe the structure and function of the protein Cup A as a chaperone that buffers copper to very low concentration--in turn protecting S.
Khleif, Director of the GRU Cancer Center, said "one of the major areas of scientific emphasis of the GRU Cancer Center is to develop therapeutic approaches to cancer targeting specific molecules within the cancer cell, including chaperones.
The Telegraph reported earlier this week that Warwickshire County Council was set to reverse the decision to axe the chaperones, which would have left pupils as young as four unaccompanied on school buses.
Professionalism in the intimate examination: How healthcare practitioners feel about having chaperones present during an intimate consultation and examination.
OK, but what happens when the chaperones yield to their own temptations and also get in trouble?
He explains that molecular chaperones protect neurons from toxic protein aggregates, which are at the root of diseases such as Alzheimer's, amyotrophic lateral sclerosis (ALS), Huntington's, Parkinson's, prion diseases, and others.
Amicus is investigating the potential use of pharmacological chaperones for the treatment of genetically defined sub-populations of patients with Parkinson's disease and Alzheimer's disease.
For further information or to volunteer as a chaperone please call Optimist Marc at 442-7964 or Optimist Tom at 442-2140.
Crowley, President and CEO of Amicus, commented, "The issuance of this patent further strengthens our protection in the United States for Plicera in Gaucher and is one example of our ongoing efforts to establish a comprehensive intellectual property portfolio for our development programs and our pharmacological chaperone technology platform.
THE other person was a chaperone to put you at your ease, not to make you feel awkward.