chaotropic agent


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chaotropic agent

An ion that disrupts membranes, nucleic acids, and proteins.
See also: agent
References in periodicals archive ?
12,13) Traditional methods for measuring antibody affinity or avidity are cumbersome; however, inclusion of a chaotropic agent to dissociate low-avidity antibodies in an EIA can provide avidity information in a simple assay.
2 g of the tissue pellet was digested by mechanical disruption and the DNA was purified by adsorption to glass milk in the presence of a chaotropic agent, according to the manufacturer's instructions (Fast Prep, Bio 101, Vista, CA).
The manual specimen preparation method isolates CMV DNA from 200 [micro]L of plasma by lysis of the virus with a chaotropic agent, guanidine thiocyanate, followed by precipitation of the DNA with isopropyl alcohol.