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challenge

 [chal´enj]
1. to administer a chemical substance to a patient for observation of whether the normal physiological response occurs.
2. in immunology, to administer antigen to evoke an immunologic response in a previously sensitized individual.
3. the administration of such a substance in order to assess for a response; called also provocation.
bronchial challenge (inhalational challenge) bronchial challenge test.

challenge

/chal·lenge/ (chal´enj)
1. to administer a substance to monitor for the normal physiological response.
2. in immunology, to administer an antigen to monitor the response in a sensitized person.

challenge

(chăl′ənj)
n.
Immunology The induction or evaluation of an immune response in an organism by administration of a specific antigen to which it has been sensitized.
v. chal·lenged, chal·lenging, chal·lenges
v.tr.
Immunology To induce or evaluate an immune response in (an organism) by administering a specific antigen to which it has been sensitized.

chal′lenge·a·ble adj.

challenge

1 a method of testing the sensitivity of an individual to a hormone, allergen, or other substance by administering a sample. A small amount may be injected to determine whether the immune system will react by producing appropriate antibodies.
2 a term used to describe the rapid or concentrated infusion of a substance such as potassium or magnesium in the face of a life-threatening deficiency or a rapid infusion of IV fluid to differentiate between fluid deficit or renal failure as the cause of severely decreased urine output.

challenge

Immunology The administration of an antigen or allergen to a person who has been previously exposed to the antigen, specifically to evoke an immune response

challenge,

n a stimulating or de-manding circumstance. To develop effective problem-solving skills and strategies, it is necessary to perceive such circumstance as inconvenience or burden instead of overwhelming impediments.
References in periodicals archive ?
Americans United, which has several lawsuits challenging faith-based funding under way, says the new legal challenge is extremely important.
This includes teaching staff proper positioning of themselves vis-a-vis residents who are behaviorally challenging, verbal communication skills, and ways to supplement verbal requests with helpful gestures and other visual cues.
Besides the physical improvement of their bodies, many participants stated that the teamwork and comradery that developed because of sharing a challenging experience proved more valuable.
reprimand), but also serve as antecedents for subsequent severe challenging behaviors (See Figure 1).
Multi-disciplinary professionals with specialist knowledge of working with deaf people explore aspects of mild to severe challenging behaviour with reference to its cause, assessment, prevention and management.
Vermeer feels involvement in real estate provides exceptional opportunities to master multiple disciplines, from finance to development, marketing to sales, to excel in a challenging industry.
Interestingly, the survey revealed that the number of companies challenging the assessments increased with the size of the company.
While this is an area of active clinical research, key to the success of this economically challenging approach is to identify the best combination of drugs and the patients that will benefit most from treatment
Through facilitated discussions, conference participants will examine some of the most challenging aspects of working collaboratively, including how to build successful partnerships and expand the role of tribes, states and communities in cooperative conservation; how to improve certainty and incentives for landowners; and how to coordinate conservation across different jurisdictions.
we're challenging brokers and consultants to let CoreSource demonstrate concrete network savings.
After the Supreme Court rejected his challenge to the Pledge last year, Newdow has now embarked a new legal campaign - filing lawsuits challenging the Pledge once again.
The American Center for Law and Justice, specializing in constitutional law, is opposing a legal challenge brought by California atheist Michael Newdow challenging the constitutionality of prayer at the Presidential inauguration.