challenge

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challenge

 [chal´enj]
1. to administer a chemical substance to a patient for observation of whether the normal physiological response occurs.
2. in immunology, to administer antigen to evoke an immunologic response in a previously sensitized individual.
3. the administration of such a substance in order to assess for a response; called also provocation.
bronchial challenge (inhalational challenge) bronchial challenge test.

challenge

/chal·lenge/ (chal´enj)
1. to administer a substance to monitor for the normal physiological response.
2. in immunology, to administer an antigen to monitor the response in a sensitized person.

challenge

(chăl′ənj)
n.
Immunology The induction or evaluation of an immune response in an organism by administration of a specific antigen to which it has been sensitized.
v. chal·lenged, chal·lenging, chal·lenges
v.tr.
Immunology To induce or evaluate an immune response in (an organism) by administering a specific antigen to which it has been sensitized.

chal′lenge·a·ble adj.

challenge

1 a method of testing the sensitivity of an individual to a hormone, allergen, or other substance by administering a sample. A small amount may be injected to determine whether the immune system will react by producing appropriate antibodies.
2 a term used to describe the rapid or concentrated infusion of a substance such as potassium or magnesium in the face of a life-threatening deficiency or a rapid infusion of IV fluid to differentiate between fluid deficit or renal failure as the cause of severely decreased urine output.

challenge

Immunology The administration of an antigen or allergen to a person who has been previously exposed to the antigen, specifically to evoke an immune response

challenge,

n a stimulating or de-manding circumstance. To develop effective problem-solving skills and strategies, it is necessary to perceive such circumstance as inconvenience or burden instead of overwhelming impediments.
References in periodicals archive ?
Khan, AU's legal director, noted that the organization is currently litigating several challenges to the faith-based initiative.
An average of 70 percent of the challenges were resolved at the local assessor's office, with about 20 percent being resolved on appeal.
Challenge: "Training a nursing staff to handle sub-acute care patients is the biggest challenge I face as a director of nursing.
Board members will consider whether any of the challenges is valid and how to proceed.
Meet the challenges to the best of your abilities and understanding.
The report shows that part Of the challenge is finding concise, unbiased, relevant information on emerging technologies specific to property management--then determining how.
College students get a taste of the real world, and dairy companies get to mingle with potential new hires and display their wares when the North American Intercollegiate Dairy Challenge (NAIDC) comes to campus.
Implementing a workshop approach to reading instruction presents many challenges for classroom teachers.
Today, the heirs of Prime Minister Yoshida are rising to the new challenges of a new era.
Training programs can also be inappropriate when they fail to consider the special challenges of working with physically frail seniors.
Price challenges can be submitted online through either the Logistics Support Activity's Logistics Integrated Data Base (LIDB) or its Weblog website.
The standardized stages - Roundabout, Showdown, Five to Go, Flying M 2000, Speed Option, Outer Limits and Smoke and Hope - are each configured to offer different challenges from plate distance and configuration.