challenge

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challenge

 [chal´enj]
1. to administer a chemical substance to a patient for observation of whether the normal physiological response occurs.
2. in immunology, to administer antigen to evoke an immunologic response in a previously sensitized individual.
3. the administration of such a substance in order to assess for a response; called also provocation.
bronchial challenge (inhalational challenge) bronchial challenge test.

challenge

/chal·lenge/ (chal´enj)
1. to administer a substance to monitor for the normal physiological response.
2. in immunology, to administer an antigen to monitor the response in a sensitized person.

challenge

(chăl′ənj)
n.
Immunology The induction or evaluation of an immune response in an organism by administration of a specific antigen to which it has been sensitized.
v. chal·lenged, chal·lenging, chal·lenges
v.tr.
Immunology To induce or evaluate an immune response in (an organism) by administering a specific antigen to which it has been sensitized.

chal′lenge·a·ble adj.

challenge

1 a method of testing the sensitivity of an individual to a hormone, allergen, or other substance by administering a sample. A small amount may be injected to determine whether the immune system will react by producing appropriate antibodies.
2 a term used to describe the rapid or concentrated infusion of a substance such as potassium or magnesium in the face of a life-threatening deficiency or a rapid infusion of IV fluid to differentiate between fluid deficit or renal failure as the cause of severely decreased urine output.

challenge

Immunology The administration of an antigen or allergen to a person who has been previously exposed to the antigen, specifically to evoke an immune response

challenge,

n a stimulating or de-manding circumstance. To develop effective problem-solving skills and strategies, it is necessary to perceive such circumstance as inconvenience or burden instead of overwhelming impediments.
References in periodicals archive ?
Considered one of the world's most mission-versatile business jets, the Challenger 350 can carry up to eight passengers in Flexjet's smart interior configuration, has a maximum operating altitude of 45,000 feet, a top cruising speed of 528 MPH and a transcontinental range of 3,200 nautical miles.
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