challenge


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challenge

 [chal´enj]
1. to administer a chemical substance to a patient for observation of whether the normal physiological response occurs.
2. in immunology, to administer antigen to evoke an immunologic response in a previously sensitized individual.
3. the administration of such a substance in order to assess for a response; called also provocation.
bronchial challenge (inhalational challenge) bronchial challenge test.

challenge

/chal·lenge/ (chal´enj)
1. to administer a substance to monitor for the normal physiological response.
2. in immunology, to administer an antigen to monitor the response in a sensitized person.

challenge

(chăl′ənj)
n.
Immunology The induction or evaluation of an immune response in an organism by administration of a specific antigen to which it has been sensitized.
v. chal·lenged, chal·lenging, chal·lenges
v.tr.
Immunology To induce or evaluate an immune response in (an organism) by administering a specific antigen to which it has been sensitized.

chal′lenge·a·ble adj.

challenge

1 a method of testing the sensitivity of an individual to a hormone, allergen, or other substance by administering a sample. A small amount may be injected to determine whether the immune system will react by producing appropriate antibodies.
2 a term used to describe the rapid or concentrated infusion of a substance such as potassium or magnesium in the face of a life-threatening deficiency or a rapid infusion of IV fluid to differentiate between fluid deficit or renal failure as the cause of severely decreased urine output.

challenge

Immunology The administration of an antigen or allergen to a person who has been previously exposed to the antigen, specifically to evoke an immune response

challenge,

n a stimulating or de-manding circumstance. To develop effective problem-solving skills and strategies, it is necessary to perceive such circumstance as inconvenience or burden instead of overwhelming impediments.
References in periodicals archive ?
In this article, I will discuss various challenges to implementing what I have described as a workshop approach to reading instruction.
With the Millennium Challenge Account, President Bush has requested a 50% total increase in foreign aid by 2006, the largest increase in U.
Select the Price Challenge Form under the Logistics Data Management Section.
a) The challenge is initiated by drawing your coin, holding it in the air by whatever means possible and state, scream, shout or otherwise verbally acknowledge that you are initiating a coin check.
He plans to challenge Preckwinkle again in next year's race for 4th Ward Democratic committeeman.
Every time you successfully face and deal with a significant challenge, you gain experience and confidence, and you'll eventually look back on your challenges with strong memories.
The Physical Training Unit (5) started the Challenge as part of a class for the NA.
For more information on the 2002 Black Enterprise/AXA Ski Challenge, at the Vail Resort in Vail, Colorado, visit our Website at www.
Tom Preston, a Seattle cardiologist and one of the doctor plaintiffs in the Washington challenge, was not heartened.
The Challenge stresses academic preparation as well as athletic prowess and are similar to the sessions of the Reebok[R] Preseason Combines held earlier in the spring for high school football players.
The Challenge product family now includes four models that span a range of capabilities: the entry Challenge S server, starting at $12,250, with the industry's best price/performance; the Challenge DM server, featuring unrivaled I/O performance; and the Challenge L and XL symmetric multiprocessing (SMP) systems introduced in January 1993.