The disease is caused by parasitic microorganisms known as trypanosomes that can destroy heart tissue leading to a condition known as Chagasic
In chronic chagasic
myocarditis the maintenance of a pro-inflammatory response is the cause of an excessive or uncontrolled heart inflammation (Rosenberg et al.
On the basis of local and limited serologic surveys, the presumptive number of chagasic
patients living in Japan is currently 4,500, compared with > 100,000 in the United States and > 6,000 in Spain (2).
Role of neurotransmitter auto-antibodies in the pathogenesis of chagasic
Postmortem diagnosis of autochthonous acute chagasic
myocarditis by polymerase chain reaction amplification of a species-specific DNA sequence of Trypanosoma cruzi.
Positive troponin T in a chagasic
patient with sustained ventricular tachycardia and no obstructive lesions on cine coronary angiography [in Portuguese].
Avila HA, Pereira JB, Thiemann O, de Paiva E, Degrave W, Morel CM and Simpson L: Detection of Trypanosoma cruzi in blood specimens of chronic chagasic
patients by polymerase chain reaction amplification of kinetoplast minicircle DNA: comparison with serology and xenodiagnosis.
However, a recently published paper showed that 74% of Venezuelan isolates from acute chagasic
patients were typed as T.
Catalina Antico Penna, director of the Argentine NGO Asociacion de Lucha Contra el Mal de Chagas (ALCHA), says, "Transfusions are also a frequent source of transmission and are much more serious, since a large quantity of infected blood enters a healthy organism, which can then collapse from Chagasic
Prolonged survival and immune reconstitution after chagasic
meningoencephalitis in a patient with acquired immunodeficiency syndrome.
Final diagnoses in non-CD patients with positive serology were undetermined in 3; irritable bowel syndrome in 4 (2 of these were 1st-degree relatives of CD patients); and colorectal cancer, choleretic diarrhea, and chagasic
megacolon in 1 patient each.
Cardiopathy was of idiopathic (25 patients), Chagasic
(16 patients), ischemic (10 patients) and hypertensive origin (5 patients).