cetirizine hydrochloride

ce·tir·i·zine hydrochloride (s

-tîr

-z

)

A nonsedating antihistamine used to treat allergic rhinitis and other allergic disorders.

cetirizine hydrochloride

AllerTec (UK), Benadryl Alergy Oral Solution (UK), Benadryl One a Day (UK), Hayfever & Allergy Relief (UK), Hayfever Relief (UK), Piriteze (UK), Reactine (CA), Zirtec (UK), Zyrtec

Pharmacologic class: Histamine₁-receptor antagonist (peripherally selective)

Therapeutic class: Allergy, cold, and cough agent; antihistamine

Pregnancy risk category B

Action

Antagonizes histamine's effects at histamine₁-receptor sites, preventing allergic response. Also has mild bronchodilatory effects and blocks histamine-induced bronchoconstriction in asthma.

Availability

Syrup: 5 mg/5 ml

Tablets: 5 mg, 10 mg

⊘Indications and dosages

➣ Allergic symptoms caused by histamine release

Adults and children older than age 6: 5 to 10 mg P.O. daily

Children ages 2 to 5: 2.5 mg to 5 mg P.O. daily

Dosage adjustment

• Renal impairment
• Hepatic impairment

Contraindications

• Hypersensitivity to drug or hydroxyzine
• Acute asthma attacks
• Angle-closure glaucoma
• Pyloroduodenal obstruction
• Breastfeeding

Precautions

Use cautiously in:
• renal impairment, significant hepatic dysfunction
• elderly patients
• pregnant patients
• children younger than age 2 (safety not established).

Administration

• Give with or without food.
• Administer at same time each day.

Route	Onset	Peak	Duration
P.O.	30 min	1-4 hr	24 hr

Adverse reactions

CNS: dizziness, drowsiness, fatigue

CV: palpitations, edema

EENT: pharyngitis

GI: nausea, vomiting, abdominal distress, dry mouth

Musculoskeletal: myalgia, joint pain

Respiratory: bronchospasm

Skin: photosensitivity, rash, angioedema

Other: fever

Interactions

Drug-drug. CNS depressants: additive CNS effects

Theophylline: decreased cetirizine clearance

Drug-diagnostic tests. Allergy skin tests: false-negative results

Drug-behaviors. Alcohol use: additive CNS effects

Sun exposure: photosensitivity

Patient monitoring

• Monitor creatinine levels in patients with renal dysfunction.
• Assess hepatic enzyme levels in patients with hepatic disease.

Patient teaching

• Tell patient to take with full glass of water.
• Inform patient that drug may impair alertness and that alcohol may exaggerate this effect.
• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.
• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, and behaviors mentioned above.

Mentioned in	?		References in periodicals archive	?		Medical browser	?		Full browser	?
Zyrtec	Food and Drug Administration ("FDA") for its Abbreviated New Drug Application ("ANDA") for cetirizine hydrochloride tablets (OTC), 5 mg and 10 mg ("Cetirizine Tablets"). Taro Receives FDA Approval for Cetirizine Hydrochloride Tablets (OTC) ... by Business Wire Food and Drug Administration ("FDA") for its Abbreviated New Drug Application ("ANDA") for prescription Cetirizine Hydrochloride Syrup, 1 mg / 1 mL ("cetirizine syrup"). Taro Receives Final FDA Approval for RX Cetirizine Hydrochloride ... by Business Wire Food and Drug Administration ("FDA") for its Abbreviated New Drug Application ("ANDA") for cetirizine hydrochloride oral solution, 1 mg / 1 mL ("Cetirizine Oral Solution"). Taro Receives Final FDA Approval for Cetirizine Hydrochloride Oral ... by Business Wire	Cesky terrier cessation cesspit cesspool fever Cestan-Chenais syndrome cesticidal cestocidal cestocide Cestoda cestodal cysts Cestodaria cestode cestode infection cestodiasis cestodology cestoid Cestoidea Cestrum CET Cetacaine cetacean cetalkonium cetalkonium chloride cetirizine cetirizine HCl cetirizine hydrochloride Cetonia aurata Cetraria islandica cetrimonium cetrimonium bromide cetrorelix cetuximab cetyl cetyl alcohol cetyl palmitate cetylpyridinium cetylpyridinium chloride CEU cevadine cevimeline cevitamic acid Ceylonocotyle Cf CFA CFIDS CFR CFS CFT CFU CG CGC	CETHV CETI CETIA CETIAT Cetic Cetic CETICOS CETIE CETIM CETIMA Cetin Cetin Cetin Cetinje Cetinje Cetinje Cetinje Municipality Cetinje Municipality Cetinje Municipality CETIOM Cetiosauridae Cetiosauridae CETIP CETIQT CETIR Cetirizine Cetirizine Cetirizine Cetirizine Cetirizine HCl cetirizine hydrochloride CETIS CETK CETL CETL-MSOR CETM CETMA CETME CETMOS CETN Cetnici Cetnik Cetnik Cetniks Ceto cetological cetological cetologist cetologist Cetologists Cetologists cetology cetology Cetomimiform Cetomimiformes Cetomimoidea Cetomimoidei Cetonia Cetonia aurata Cetonia aurata Cetonian Beetles

Mentioned in

References in periodicals archive

Medical browser

Full browser

Zyrtec

Food and Drug Administration ("FDA") for its Abbreviated New Drug Application ("ANDA") for cetirizine hydrochloride tablets (OTC), 5 mg and 10 mg ("Cetirizine Tablets").

Taro Receives FDA Approval for Cetirizine Hydrochloride Tablets (OTC) ... by Business Wire

Food and Drug Administration ("FDA") for its Abbreviated New Drug Application ("ANDA") for prescription Cetirizine Hydrochloride Syrup, 1 mg / 1 mL ("cetirizine syrup").

Taro Receives Final FDA Approval for RX Cetirizine Hydrochloride ... by Business Wire

Food and Drug Administration ("FDA") for its Abbreviated New Drug Application ("ANDA") for cetirizine hydrochloride oral solution, 1 mg / 1 mL ("Cetirizine Oral Solution").

Taro Receives Final FDA Approval for Cetirizine Hydrochloride Oral ... by Business Wire