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ceruloplasmin

   Also found in: Dictionary/thesaurus, Acronyms, Wikipedia 0.06 sec.
ceruloplasmin /ce·ru·lo·plas·min/ (sĕ-roo″lo-plaz´min) an α2-globulin of plasma believed to function in copper transport and its maintenance at appropriate levels in tissue; levels are decreased in Wilson's disease.
ce·ru·lo·plas·min (s-rl-plzmn)
n.
A blue, copper-containing globulin that may play a part in erythropoiesis and oxygen reduction.

Ceruloplasmin
A protein circulating in the bloodstream that binds with copper and transports it.
Mentioned in: Wilson Disease

ceruloplasmin
[siro̅o̅′lōplaz′min]
Etymology: L, caelum, sky; Gk, plassein, to shape
a blue glycoprotein in plasma that transports 96% of the plasma copper. A major decrease is seen in Wilson's disease.

ceruloplasmin
an alpha2-globulin of the plasma, being the form in which most of the plasma copper is transported. Used as a measure of the copper status of animals.

ceruloplasmin
Ferroxidase Clinical chemistry A dehydrogenase produced in the liver involved in copper detoxification and possibly in mopping up excess oxygen radicals or superoxide anions ↑ in Neoplasms, inflammation, liver disease, rheumatoid arthritis, SLE, pregnancy, OCs, estrogen therapy ↓ in Wilson's disease, Menkes' kinky hair syndrome, hepatitis, cirrhosis, nephrotic syndrome, sprue, scleroderma of small intestine. See Copper.


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In addition, Cu,Zn-superoxide dismutase (SOD1) and ceruloplasmin (Cu-binding protein) were also increased approximately 3-fold by arsenic.
12], ceruloplasmin, CSF analysis, thyroid panel, CHEM-7, and CBC) were ordered, all of which were negative or within normal limits.
Ceruloplasmin and hephaestin may facilitate iron transport by altering chemical properties of the metal, although that remains unproved.
 
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