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ceroid

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ceroid
[sir′oid]
Etymology: L, cera, wax; Gk, eidos, form
a golden, waxy pigment appearing in the cirrhotic livers of some individuals, in the GI tract, in the nervous system, and in the muscles. It is an insoluble, acid-fast, sudanophilic pigment.
ceroid
an insoluble polymer of oxidized lipid and protein; an acid-fast, sudanophilic, pigment found in the liver, the nervous system and muscle. See also ceroid lipofuscinosis.
ceroid
A complex of alcohol-insoluble, oxidized polyunsaturated lipid pigment(s) resulting from the peroxidation of unsaturated lipids that are similar or identical to lipofuscin; ceroid accumulates in macrophages of the heart, liver, GI tract, and brain in the elderly and is thus termed 'wear and tear' pigment; it has been inculpated in age-related organ dysfunction–see 'garbage can' hypothesis, hypovitaminosis E, cathartic colon, and hereditary conditions–eg, Batten's disease, sea-blue histiocytosis
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Batten disease is the most common form of a group of rare disorders known as neuronal ceroid lipofuscinoses (NCLs).
Batten Disease ? Causes of Batten Disease by Peter Sams / Health, general community
Also known as Spielmeyer-Vogt-Sjogren-Batten Disease, it is the most common form of a group of disorders called Neuronal Ceroid Lipofuscinoses, or NCLs.
A tragic condition by Evening Chronicle (Newcastle, England)
Palo Alto, CA, announced it has received approval from the Institutional Review Board (IRB) of the Oregon Health & Science University (OHSU), Portland, OR, to initiate a Phase I clinical trial of the company's proprietary human neural stem cell product - HuCNS-SC - to treat infantile and late-infantile neuronal ceroid lipofuscinosis (NCL), two forms of a group of disorders often referred to as Batten disease.
StemCells receives IRB approval from OHSU to begin Phase I clinical ... by Transplant News
 
 
 
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