This same manufacturer had previously been accused of hiding unfavorable data in connection with another medication, cerivastatin
HMG-CoA reductase inhibitors ("statins") are the most commonly prescribed lipid-lowering agents and most of them (atorvastatin, cerivastatin
, lovastatin, simvastatin) are metabolized by the CYP3A4 isoform of the CYP450 cytoehrome system.
Although hindsight always raises questions about whether a problem could have been detected earlier, the events surrounding cerivastatin
serve as a clear example of how the system should work," he says.
A spokesman for pharmaceutical firm Bayer plc said Cerivastatin
, also known as Lipobay, had been withdrawn after reports that it could cause muscle breakdown when used in conjunction with gemfibrozil, another drug used to lower cholesterol.
(Baycol) and gemfibrozil should not be taken as a combination.
STUDIES ON NEURAL TUBE DEFECTS: EFFECTS OF CERIVASTATIN
was linked to 52 fatalities from rhabdomyolysis, a serious muscle myopathy that led to death.
Rapid reduction in C-reactive protein with cerivastatin
among 785 patients with primary hypercholesterolemia.
In August 2001 Bayer pulled cerivastatin
(Baycol) off the market because of fatal rhabdomyolysis (a condition that results in muscle cell breakdown and release of the contents of muscle cells into the blood).
Additive effect of plant sterol-ester margarine and cerivastatin
in lowering low density lipoprotein cholesterol in primary hypercholesterolemia.
320 Since bronchoscopy in 2001 Candesartan NA Until April 2004 Celecoxib 200 July 2001 until July 2003 Cerivastatin
NA Since 1995 until 1998 Chloroquine NA July 2001 until 2003 Clomipramine 12.
All defects involved a lipophilic statin (atorvastatin, cerivastatin
[Baycol], lovastatin, or simvastatin).