cerivastatin


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cerivastatin

 [sĕ-riv´ah-stat″in]
an inhibitor of an enzyme involved in the biosynthesis of cholesterol; used as an adjunct in the treatment of hyperlipidemia. Withdrawn in the United States because it is associated with an increased risk for rhabdomyolysis.

cerivastatin

an HMG-CoA reductase inhibitor (Baycol) withdrawn from the market in August 2001 after several cases of fatal rhabdomyolysis.

cerivastatin

Baycol® Cardiology Cholesterol-lowering, HMG-CoA reductase inhibitor/statin for managing hypercholesterolemia and mixed dyslipidemia; it ↑ HDL-C and ↓ LDL-C; withdrawn from the market as it was linked to rhabdomyolysis. See Statin.
References in periodicals archive ?
This same manufacturer had previously been accused of hiding unfavorable data in connection with another medication, cerivastatin.
HMG-CoA reductase inhibitors ("statins") are the most commonly prescribed lipid-lowering agents and most of them (atorvastatin, cerivastatin, lovastatin, simvastatin) are metabolized by the CYP3A4 isoform of the CYP450 cytoehrome system.
Although hindsight always raises questions about whether a problem could have been detected earlier, the events surrounding cerivastatin serve as a clear example of how the system should work," he says.
A spokesman for pharmaceutical firm Bayer plc said Cerivastatin, also known as Lipobay, had been withdrawn after reports that it could cause muscle breakdown when used in conjunction with gemfibrozil, another drug used to lower cholesterol.
Also, cerivastatin (Baycol) and gemfibrozil should not be taken as a combination.
STUDIES ON NEURAL TUBE DEFECTS: EFFECTS OF CERIVASTATIN
Cerivastatin was linked to 52 fatalities from rhabdomyolysis, a serious muscle myopathy that led to death.
Rapid reduction in C-reactive protein with cerivastatin among 785 patients with primary hypercholesterolemia.
In August 2001 Bayer pulled cerivastatin (Baycol) off the market because of fatal rhabdomyolysis (a condition that results in muscle cell breakdown and release of the contents of muscle cells into the blood).
Additive effect of plant sterol-ester margarine and cerivastatin in lowering low density lipoprotein cholesterol in primary hypercholesterolemia.
320 Since bronchoscopy in 2001 Candesartan NA Until April 2004 Celecoxib 200 July 2001 until July 2003 Cerivastatin NA Since 1995 until 1998 Chloroquine NA July 2001 until 2003 Clomipramine 12.
All defects involved a lipophilic statin (atorvastatin, cerivastatin [Baycol], lovastatin, or simvastatin).