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cerebellar ataxia |
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cerebellar ataxia Etymology: L, cerebellum, small brain; Gk, ataxia, without order a loss of muscle coordination caused by a lesion in the cerebellum. ataxia failure of muscular coordination; irregularity of muscular action. cerebellar ataxia ataxia characterized by defects in rate, range, force and direction of movement of limbs. There is a broad based stance, inability to maintain the head in the proper position so that it oscillates, there is hypermetria or hypometria, direction cannot be maintained and the animal falls easily, often in an exaggerated way. congenital ataxia cerebellar ataxia due to viral infection of the fetus, e.g. bovine virus diarrhea and feline panleukopenia, or to inheritance, e.g. in cattle. See also cerebellar atrophy. copper-related ataxia see copper nutritional deficiency. enzootic ataxia see enzootic ataxia. equine sensory ataxia see enzootic equine incoordination. familial convulsions and ataxia of cattle see familial convulsions and ataxia of cattle. feline ataxia see feline panleukopenia. foal ataxia see enzootic equine incoordination. frontal ataxia disturbance of equilibrium occurring in cases of tumor of the frontal lobe. hereditary ataxia see hereditary ataxia. hound ataxia a degenerative myelopathy of Foxhounds, Harrier hounds and Beagles. Affected dogs show increasing hindleg incoordination. A dietary cause is suspected. locomotor ataxia tabes dorsalis. otarid ataxia a syndrome in pinnipeds caused by nutritional deficiency of thiamin or enterotoxemia or hypoglycemia. Signs include heelwalking (elevation and curling of the rear toes) followed by running staggers, ataxia and violent falling. progressive ataxia an inherited disease of cattle in which hind limb ataxia commences at 6 months to 3 years of age and worsens over 1 to 2 more years to the point of recumbency. It is a myelin disorder with eosinophilic plaques in the cerebellar medula and peduncles. Called also progressive sensory ataxia of Charolais cattle. sensorimotor ataxia caused by moderate spinal cord lesions, manifested by weakness of movement, scuffing of toes, incomplete limb extension, knuckling, wobbly gait, easy falling, difficult rising. sensory ataxia ataxia due to loss of proprioception (joint position sense), resulting in poorly judged movements and becoming aggravated when the eyes are blindfolded. spinal ataxia see equine protozoal myeloencephalitis. vestibular ataxia a loss of balance with preservation of strength. If unilateral, the abnormality is asymmetrical; if bilateral, it is symmetrical. cerebellar pertaining to the cerebellum. cerebellar abiotrophy occurs in cattle, pigs and dogs. Affected young are normal at birth but at an early age ataxia and signs of cerebellar dysfunction appear, often progressing to complete immobilization. Cerebral function is usually normal. An inherited basis is suspected. In Kerry blue terriers, it is inherited as an autosomal recessive trait. Called also cerebellar neuronal abiotrophy. cerebellar agenesis absence of the cerebellum due to its non-appearance in the embryo. cerebellar aplasia see cerebellar atrophy (below). cerebellar ataxia the incoordination of gait characterized by exaggerated movements. There is no paresis. There is exaggerated strength and distance of movement—hypermetria. Caused usually by damage to the cerebellum or to the spinocerebellar tracts. May be congenital due to cerebellar atrophy or acquired due to inflammation or malacia of the cerebellum. cerebellar atrophy degeneration and loss of cells—Purkinje and granular cells of the cerebellum. Present at birth or soon after, is congenital in sheep, cattle, Arab horses, dogs and cats. Some of the diseases are inherited, some are known to be due to virus infection in utero, e.g. bovine virus diarrhea, feline panleukopenia. Some are in fact abiotrophies, premature aging of tissues. In the latter the animals are normal at birth but develop classical signs later. Segmental atrophy occurs in pigs but is asymptomatic. cerebellar coning see cerebellar lipping (below), brain herniation. cerebellar cortex the superficial gray matter of the cerebellum. cerebellar dysfunction see cerebellar ataxia (above). cerebellar dysmelinogenesis recorded in Chow Chow dogs; characterized by congenital head tremor. feline cerebellar ataxia see feline panleukopenia. cerebellar hypomyelinogenesis abnormally reduced myelination in the cerebellum; characterized clinically by severe neonatal tremor. cerebellar hypoplasia deficiency of cells of the cerebellum, the degree and distribution of which is variable. See cerebellar atrophy (above). inherited cerebellar defects includes cerebellar abiotrophy, atrophy, agenesis, hypoplasia, neuraxonal dystrophy. cerebellar lipping caused by diffuse cerebral edema. The vermis of the cerebellum protrudes through the foramen magnum and lies like a tongue over the medulla. cerebellar neuronal abiotrophy see cerebellar abiotrophy (above). cerebellar neuraxonal dystrophy reported in collie sheepdogs. The lesion is limited to axons and there are no lesions in the cerebellar folial neurons. cerebellar syndrome see cerebellar ataxia (above). cerebellar ataxia Neurology A condition characterized by a usually abrupt onset of unsteady gait, nystagmus, and dysarthria, which in children may persist in the form of residual movement or behavioral disorders. See Ataxia. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Infections that primarily result in cerebellar dysfunction are rare, with the most common being acute cerebellar ataxia of childhood that has been attributed to various viruses including echo, Coxsackie groups A and B, Epstein-Barr, and herpes simplex. She has served as principal investigator (PI) on grants totaling more than $1 million and is currently the PI on a 4-year $650,000 award, "Mechanisms and Rehabilitation of Cerebellar Ataxia," from NIH's National Institute of Child Health and Human Development ( Several years ago, DiMauro, a neurologist at Columbia University College of Physicians and Surgeons in New York, had noticed that muscle tissue from a patient with familial cerebellar ataxia had a deficiency in a compound called |
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