ceramidase


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ceramidase

 [sĕ-ram´ĭ-dās]
an enzyme occurring in most mammalian tissue that catalyzes the reversible acylation (incorporation of an acid radical) and deacylation (loss of an acid radical) in ceramides.

cer·am·i·dase

(ser-am'i-dās),
An enzyme that hydrolyzes ceramides into sphingosine and a fatty acid; acylsphingosine deacylase. A deficiency of this enzyme is associated with disseminated lepogranulomatosis.

ceramidase

/cer·am·i·dase/ (ser-am´ĭ-dās) an enzyme occurring in most mammalian tissue that catalyzes the reversible acylation-deacylation of ceramides.

ceramidase

[səram′idās]
an enzyme of the hydrolase class that catalyzes the cleavage of a ceramide to form sphingosine and a fatty acid anion, a step in the degradation of sphingolipids. See also Farber's disease.

cer·am·i·dase

(sĕr-am'i-dās)
An enzyme that hydrolyzes ceramides into sphingosine and a fatty acid. A deficiency of this enzyme is associated with disseminated lipogranulomatosis.

ceramidase

an enzyme occurring in most mammalian tissue that catalyzes the reversible acylation-deacylation of ceramides.
References in periodicals archive ?
Liu, IRF8 Regulates Acid Ceramidase Expression to Mediate Apoptosis and Suppresses Myelogeneous Leukemia, J.
In this study we have evaluated the pro-apoptotic effect of ceranib-2, a human ceramidase inhibitor and of a short-chain C2 ceramide on human lung adenocarcinoma cells, A549 by determining cytotoxicity of these agents by trypan blue assay, apoptosis inducing ability by annexin V and JC-1 staining and ultrastructural alterations by transmission electron microscopy.
Awards for original research papers published in the Hamdan Medical Journal are: - Purification and biochemical characterisation of a second type of neutral ceramidase from camel (Camelus dromedarius) brain, by Sehamuddin Galadari, Cell signalling laboratory, Department of Biochemistry, College of Medicine and Health Sciences, UAE University, Al Ain, UAE.
Purification and biochemical characterisation of a second type of neutral ceramidase from camel (Camelus dromedarius) brain', by Sehamuddin Galadari, Cell signalling laboratory, Department of Biochemistry, College of Medicine and Health Sciences, UAE University, Al Ain, UAE
Plexcera Therapeutics, a US-based company that develops human acid ceramidase to treat related diseases, has been granted an exclusive commercial development licence by Mount Sinai Innovation Partners (MSIP), part of the Icahn School of Medicine at Mount Sinai, it was reported yesterday.
048 RND2, SEMA4D neurons Abbreviations: ACER2, alkaline ceramidase 2; FUT4, fucosyltransferase 4; GCNT1, glucosaminyl (N-acetyl) transferase 1, core 2; MAN1B1, mannosidase, alpha, class 1B, member 1; NEU1, sialidase 1 (lysosomal sialidase); RND2, Rho family GTPase 2; SEMA4D, sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D; SGPL1, sphingosine-1-phosphate lyase 1; ST8SIA4, ST8 alpha-N-acetyl-neuraminide alpha-2, 8-sialyltransferase 4; TNFAIP3, tumor necrosis factor, alpha-induced protein 3; TNFR1, tumor necrosis factor binding protein 1.
Novel pathway of ceramide production in mitochondria: thioesterase and neutral ceramidase produce ceramide from sphingosine and acyl-CoA.
As for the mechanism involved in the decreased production of sphingosine in atopic dermatitis, analysis of the activities of ceramidases, major sphingosine-producing enzymes, revealed that, whereas the activity of alkaline ceramidase did not differ between patients with atopic dermatitis and healthy controls, the activity of acid ceramidase was significantly reduced in patients with atopic dermatitis and this had obvious relevance to the increased colonization of bacteria in those subjects.
D-galactosyl-sn -glycerol + 2 carboxylates Ceramidase 3.
It is composed of a calcium compound and a ceramidase inhibitor, and exhibits three main actions, which have been demonstrated in vitro to promote the structuring and stabilization of the stratum corneum.