CLSI mandates reporting methieillin-/oxacillin-resistant staphylococci resistant to all beta-lactam drugs--penicillins, cephalosporins, cephamycin
, and beta-lactam/beta-lactam inhibitors and carbapenems.
Other successful preventive infection-control measures include strict hand washing and restricted use of cephalosporin and cephamycin
antibiotics that promote resistance in Acinetobacter .
therapy leads to emergence of plasmid mediated Amp C resistance.
In addition, altered expression of outer membrane proteins constituting porins can also contribute to cephamycin resistance (6).
Cephamycin resistance in clinical isolates and laboratory-derived strains of Escherichia coli, Nova Scotia, Canada.
Characterization of the plasmidic [beta]-lactamase CMY-2, which is responsible for cephamycin resistance.
He founded the Fermentation Microbiology Department at Merck and directed research and development for several products, including monosodium glutamate, vitamin B12, streptomycin, riboflavin, cephamycin
, fosfomycin and interferon inducers.
Even though the cephamycin antibiotics--cefotetan, cefmetazole, and cefoxitin--may appear to test susceptible, their usefulness in treating serious infections with ES[beta]L producers is unclear.
12,13) Interestingly, they are, so far, unable to hydrolyze the cephamycin antibiotics cefotetan, cefmetazole, and cefoxitin, which are close relatives of the cephalosporins.
In addition, mutation or altered expression of outer membrane proteins constituting porins can also contribute to cephamycin resistance.
On the other hand, the widespread clonal dissemination of strains that hyperproduce AmpC by virtue of promoter or attenuator mutations suggests that they are much better able and more likely to contribute to the spread of cephamycin resistance.
Enterobacteriaceae with plasmid-encoded class C cephalosporinases are typically resistant to cephamycins
, extended-spectrum cephalosporins, and monobactams (19).