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cephalosporinase

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cephalosporinase /ceph·a·lo·spo·rin·ase/ (-spor´in-ās) a β-lactamase preferentially acting on cephalosporins.
ceph·a·lo·spor·i·nase (sf--l-spôr-ns, -nz)
n.
See beta-lactamase.
cephalosporinase.
cephalosporinase
an enzyme that hydrolyzes the −CO−NH− bond in the lactam ring of cephalosporin, converting it to an inactive product.


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However, a few carbapenem-resistant enterobacterial isolates have been reported; resistance may be caused by production of carbapenemases (2) or by combined mechanisms of an outer membrane permeability defect and extended-spectrum [beta]-lactamases or cephalosporinase (3-6).
Ertapenem resistance of Escherichia coli by Nordmann, Patrice / Emerging Infectious Diseases
Possible mechanisms for ceftazidime resistance among gram-negative bacilli are alterations in outer membrane proteins, overproduction of cephalosporinase, or production of an extended-spectrum [beta]-lactamase (ESBL).
VEB-1 in Achromobacter xylosoxidans from cystic fibrosis patient, ... by Siebor, Eliane / Emerging Infectious Diseases
A synergy image, signature of the presence of an ESBL, could not be observed between clavulanic acid and cefepime or ceftazidime disks on a routine antibiogram (Figure 3A) unless cloxacillin-containing plates that inhibit cephalosporinase activity were used (Figure 3B).
VEB-1 extended-spectrum [beta]-lactamase--producing Acinetobacter ... by Nordmann, Patrice / Emerging Infectious Diseases
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