cephalosporin C

ceph·a·lo·spo·rin C

an antibiotic with activity due to the 7-aminocephalosporanic acid portion of the cephalosporanic acid molecule; it is effective against gram-positive and gram-negative bacteria, but is less potent than cephalosporin N. Addition of side chains produced semisynthetic broad spectrum antibiotics with greater antibacterial activity than that of cephalosporin C; the antibiotic activity is due to interference with bacterial cell-wall synthesis.

ceph·a·lo·spo·rin C

(sefă-lō-spōrin)
Antibiotic effective against gram-positive and gram-negative bacteria.
References in periodicals archive ?
Cephalosporin C (CPC) was the second [beta]-lactam antibiotics to be discovered after penicillin from the fungus Cephalosporium acremonium by Giuseppe Brotzu (1,2).
According to the diversity in substrate specificity, CAs can be divided into two classes, the cephalosporin C (CPC) acylase and the glutaryl-7-aminocephalosporanic acid (GL-7-ACA) acylase classes.
The types of cephalosporin acylase are: type 1 is true cephalosporin C acylase.
The natural of cephalosporin C acylase catalyzed the CPC to 7-ACA directly in a very low efficiency (14,15,16), significant substrate inhibition (14), and product inhibition (14).
The biotransformation of cephalosporin C to 7-ACA in one step enzymatic with cephalosporin acylase is a simple process with low cost and potential to applied in industrial production.
The protein engineering of cephalosporin C acylase was developed to increase its activity and stability of CPC acylase.
Cephalosporin C acylase from Pseudomonas species: Production and enhancement of its activity by optimization of process parameters.
Single step bioconversion of cephalosporin C by strain of Achromobacter species isolated from rhizosphere soil, Adv.
Overexpression of synthesized cephalosporin C acylase containing mutations in the substrate transport tunnel, J.
Determination of the second autoproteolytic cleavage site of cephalosporin C acylase and the effect of deleting its flanking residues in the a-C-terminal region, J.
Media optimization for the production of cephalosporin C acylase from a novel bacterial source: Alcaligenes xylosoxidans MTCC+491, Res.
Lei, Y, Zhu, Y Site-directed mutagenesis of cephalosporin c acylase and enzymatic conversion of cephalosporin C to 7-aminocephalosporanic acid, Turk.