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cephalosporin

   Also found in: Dictionary/thesaurus, Encyclopedia, Wikipedia, Hutchinson 0.06 sec.
cephalosporin /ceph·a·lo·spo·rin/ (sef?ah-lo-spor´in) any of a group of broad-spectrum, penicillinase-resistant antibiotics from Acremonium, related to the penicillins in both structure and mode of action. Those used medicinally are semisynthetic derivatives of the natural antibiotic cephalosporin C. First-generation cephalosporins have a broad range of activity against gram-positive organisms and a narrow range of activity against gram-negative organisms; second-, third-, and fourth generation agents are progressively more active against gram-negative organisms and less active against gram-positive organisms.
ceph·a·lo·spo·rin (sf--l-spôrn)
n.
Any of various broad-spectrum antibiotics, closely related to the penicillins, that were originally derived from the fungus Cephalosporium acremonium and are used to treat bacterial infections.

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Ceftobiprole is the first anti-MRSA broad-spectrum cephalosporin to demonstrate efficacy in a large clinical trial in patients infected with staphylococcal infections, including methicillin-resistant Staphylococcus aureus (MRSA).
Four patients with penicillin allergy were given clindamycin rather than a cephalosporin.
With the approval of ceftriaxone, APP retains its position with the largest portfolio of anti-infectives in the generic injectables industry and its leadership position in the cephalosporin market.
 
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