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centromere

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centromere /cen·tro·mere/ (-mēr) the clear constricted portion of the chromosome at which the chromatids are joined and by which the chromosome is attached to the spindle during cell division.centromer´ic
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Position of the centromere in (A) metacentric; (B) submetacentric; (C) acrocentric; and (D) telocentric chromosomes.

cen·tro·mere (sntr-mîr)
n.
The most condensed and constricted region of a chromosome to which the spindle fiber is attached during mitosis. Also called kinetochore.

Centromere
The centromere is the constricted region of a chromosome. It performs certain functions during cell division.

centromere (cen)
[sen′trəmir]
Etymology: Gk, kentron + meros, part
the constricted region of a chromosome that joins the two chromatids to each other and attaches to spindle fibers in mitosis and meiosis. During cell division the centromeres split longitudinally, half going to each of the new daughter chromosomes. The position of the centromere is constant for a specific chromosome and is identified as acrocentric, metacentric, submetacentric, or telocentric. Also called kinetochore, kinomere, primary constriction. centromeric, adj.

centromere [sen´tro-mēr]
the clear constricted portion of the chromosome at which the chromatids are joined and by which the chromosome is attached to the spindle during cell division. adj., adj centromer´ic.
 Position of the centromere in A, metacentric, B, submetacentric, C, acrocentric, and D, telocentric chromosomes. From Dorland's, 2000.

centromere
the clear constricted portion of the chromosome at which the chromatids are joined and by which the chromosome is attached to the spindle during cell division.


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The functional but evolutionarily immature centromere in the horse may provide a model to study factors responsible for how centromeres function.
Chromosome enumeration probes hybridize to repetitive DNA sequences located near chromosome centromeres, and because the loss of a centromere is generally indicative of the loss of an entire chromosome, they are used to enumerate the number of copies of a certain chromosome within a cell.
Other topics include orthology and functional conservation in eukaryotes, mammalian meiotic recombination hot spots, epigenetic control of centromere behavior, Mendelian genetics of apomixis in plants, and immunoglobulin somatic hypermutatoin.
 
 
 
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