A variant of the centroblastic form is the centroblast
with multilobated nuclei (Figure 1, B).
If the number of centroblasts
is more than 15 per high-powered field, the diagnosis is grade 3.
The follicles are composed of a mixed cell population, however, centroblasts
are usually the predominant cell type.
Excisional biopsy was performed and pathologic examination of the specimen showed a lymphoepithelial lesion rich in plasma cells, centroblasts
, and immunoblast-like cells.
Early phases of HIV infection often present with generalised lymphadenopathy and a LN biopsy at this time often shows giant follicles predominantly composed of centroblasts
with a starry-sky pattern.
It is unclear whether rituximab can affect centroblasts
(germinal centre-like cells) reported to be present in the CNS of MS patients, and whether this is required for rituximab to have clinical benefit.
The neoplastic cells vary from small to large, showing folding and cleaving of the nuclei, resembling centrocytes (small- to medium-sized cleaved cells with inconspicuous nucleoli) and centroblasts
(large noncleaved cells with vesicular chromatin and several peripheral nucleoli).
2,3) Interestingly, it was noted that patients with a diffuse, monotonous infiltrate of centroblasts
and/or immunoblasts had a worse prognosis.
Primary cutaneous large B-cell lymphomas (leg type) (PCBLS) are diffuse large cell B-cell lymphomas with predominance or confluent sheets of centroblasts
When naive B-cells (BCL6-, MUM1-, CD 138-) enter the germinal centre, they become centroblasts
(BCL6+, MUM1-, CD138-) that subsequently mature into centrocytes (BCL6+, MUM1-, CD138+) as they undergo immunoglobulin class switching, somatic hypermutation of the immunoglobulin variable genes and mutations of the proto-oncogene BCL6.
Most primary gastrointestinal lymphomas, both in stomach and intestine and irrespective of their association with MALT, are large B-cell lymphomas, especially those composed of centroblasts
, but may also include cases dominated by immunoblasts and, on occasion, plasmablasts.
Immunostains are helpful, as the centrocytes and centroblasts
of the neoplastic follicles in follicular lymphoma are typically CD10, BCL-6, and BCL-2 positive.