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centrilobular
(redirected from centrilobular necrosis)

   Also found in: Acronyms 0.01 sec.
centrilobular /cen·tri·lob·u·lar/ (sen″trĭ-lob´u-ler) pertaining to the central portion of a lobule.
cen·tri·lob·u·lar (sntr-lby-lr)
adj.
Relating to or being at or near the center of a lobule, as of an internal organ.

centrilobular
[sen′trəlob′yələr]
Etymology: Gk, kentron + L, lobulus, small lobe
pertaining to the center of a lobule.

centrilobular
pertaining to the central portion of a lobule.

centrilobular necrosis
necrosis restricted to the hepatocytes immediately surrounding the central venule. Called also periacinar necrosis.


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In addition, four of the five animals exhibited diffuse hepatocytic necrosis; only one liver (animal 19) had centrilobular necrosis.
For example, with acute acetaminophen exposure, the process is acute hepatic centrilobular necrosis and repair; however, specific morphological diagnoses vary with time and dose.
 
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