centrilobular emphysema


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cen·tri·lob·u·lar em·phy·se·ma

emphysema affecting the central portion of secondary pulmonary lobules, around the central bronchiole, typically involving the superior part of the lungs or lobes; may be related to inflammation of the bronchioles and to the effects of inhaled dust, which aggregates next to respiratory bronchioles; seen in coalworker's pneumoconiosis and (in mild form) asymptomatic city dwellers.

centrilobular emphysema

cen·tri·lob·u·lar em·phy·se·ma

(sen'tri-lob'yū-lăr em'fi-sē'mă)
Emphysema affecting the lobules around their central bronchioles, causally related to bronchiolitis, and seen in coal-miner's pneumoconiosis.
Synonym(s): centriacinar emphysema.
References in periodicals archive ?
The development of regional airspace disease with scattered areas of radiolucency in a patient with centrilobular emphysema has previously been described in patients with pneumonia and has been termed a "Swiss Cheese" appearance, which describes non-uniformly perforated emphysematous lung tissue amidst dense consolidation.
C, HRCT image of the same case showing circumscribed areas of paraseptal and centrilobular emphysema in the upper zones, with associated reticulation extending to the subpleural regions (arrows).
Morphologic lesions of COPD, where reported, are indeed common; for example, 9 of 10 patients with RBILD (90%), described by Moon et al, (4) had centrilobular emphysema (see comments below on imaging).
However, alveolar wall fibrosis is also seen as a part of coexisting centrilobular emphysema (Figure 6).
Foci of centrilobular emphysema can be associated with fibrosis, as is well known to pathologists who work on COPD but is largely unknown outside this group.