High-resolution CT of the chest in PVOD is characterized by 1) centrilobular
ground-glass opacities, 2) septal lines, and 3) mediastinal lymphadenopathy.
Liver biopsy showed centrilobular
necrosis with inflammatory cell infiltration compatible with a toxic etiology (Fig.
Incomplete compensation of enhanced hepatic oxygen consumption in rats with alcoholic centrilobular
It has been reported that acetaminophen causes a potentially fatal, hepatic centrilobular
necrosis when taken in overdose .
The radiologic findings are similar to those associated with pulmonary MZL and consist mainly of ground-glass attenuation, centrilobular
nodules, thickening of broncho-vascular bundles, reticular shadows, and interlobular septal thickening in the peripheral lung.
In asthmatics, moderate-to-severe central bronchiectasis affecting 3 or more lobes, bronchial wall thickening, mucoid impaction, and centrilobular
lung nodules are suggestive of allergic bronchopulmonary aspergillosis (ABPA) (Figure 2).
Thoracic computed tomography (CT) showed diffuse bilateral centrilobular
lung nodules, paraaortic lymph node enlargement, and a small splenic lesion.
Serial level HRCT images reveal diffuse centrilobular
nodular infiltrates and ground glass opacification (GGO) in both lung fields.
Dietary exposure to perfluorooctanoate or perfluorooctane sulfonate induces hypertrophy in centrilobular
hepatocytes and alters the hepatic immune status in mice.
The prevalence of airways disease on CT (air trapping, bronchial wall thickening, bronchiectasis, and/or centrilobular
opacities) was 77% in the autoantibody-positive preclinical RA group, compared with 31% of controls.
The liver exhibited diffuse centrilobular
congestion and necrosis, and the kidneys exhibited bilateral cortical infarcts and acute tubular necrosis.
NYU School of Medicine researchers found an abundance of dendritic cells in the liver can protect the organ from acetaminophen damage while low levels of dendritic cells in the liver are associated with exacerbated liver damage, liver cell and tissue death, known as centrilobular
hepatic necrosis, and acute liver failure from acetaminophen.