Hepatic abnormalities were characterized by hepatocyte cord atrophy (53%), fatty degeneration (27%), centrilobular
necrosis (22%), erythrophagocytosis (25%), hemosiderosis (22%), cholestasis (20%), and extramedullary hematopoiesis (18%).
Cigarette smoking can result in either panlobular emphysema (PLE) or centrilobular
emphysema (CLE), and the latter shows worse remodeling and narrowing of small airways, which can result in the airflow obstruction similar to asthma.
Histologically, liver lesions include congestion of the hepatic sinusoids, focal hemorrhages, centrilobular
fatty cytoplasmic vacuolation and/or necrosis, biliary hyperplasia and nodular lymphoid infiltration (Leeson et al.
A cellular stellate centrilobular
lesion is noted just to the left of center (A).
Furthermore, presence of centrilobular
nodule, location and multiplicity of cavities, location of enlarged lymph nodes classified as mediastinal, hilar, or both, were also assessed.
Liver sections of HandE demonstrated liver injury characterized by centrilobular
hepatocellular necrosis, CD68, and Bax expressions were also increased.
Figure 2d showed a mouse treated with acetaminophen with extensive centrilobular
necrosis, hydropic degeneration of hepatocytes, destruction of central vein endothelium, karyolysis, pyknosis, and karyorrhexis of nuclei.
Sponge Lung" describes the appearance of scattered centrilobular
lucencies surrounded by reticular and alveolar opacities, creating the appearance of a sponge on radiographs and CT.
Vascular congestion was present with centrilobular
necrosis, marked by pyknotic nuclei and vacuoles.
Histopathological examination of liver tissue indicated that acute APAP overdose caused marked liver tissue damage in the form of centrilobular
necrosis, granular degeneration of hepatocytes and infiltration of inflammatory cells.
Numerous studies have shown that long-term or acute AMD use causes steatosis, fibrosis in portal and sinusoidal area, neutrophil infiltration, centrilobular
necrosis and ballonning degeneration and Mallory bodies in hepatocytes of liver in humans and animals models (Poucellet al.
25 also observed that liver restored most of its normal structure and was able to diminish fibrosis, congestion, inflammatory cells infiltration, centrilobular
hepatocyte swelling and hepatocyte vacuolization in lead-induced hepatotoxicity after co treatment with Allium sativum.