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In 1952, Gough (5) used paper-mounted sections to describe what he termed "fundamentally different" types of emphysema, types that we now know as centriacinar (centrilobular) and panacinar (panlobular) emphysema.
Three types centriacinar, panacinar, and distal acinar
The development of centriacinar emphysema is believed to be closely related to cigarette smoking [25].
Figure 4A shows that O-MWCNTs delivered by OPA caused centriacinar bronchiolitis/ alveolitis in mice in three of four labs (ML1, ML2, and ML3).
Depending on the anatomical location of airway destruction, emphysema can be classified into four major subtypes; centriacinar, panacinar, paraseptal and irregular (Kumar 2005).
Further, the density Ki67-positive cells at distal perivascular-peribronchiolar areas and centriacinar regions was more prominent in [Il10.
From this centriacinar position, fibrosis extends outward until it ultimately links adjacent bronchioles; at which time, the initial, predominantly peribronchiolar pattern of fibrosis may no longer be evident (Figure 9, B through D).
Atypical adenomatous hyperplasia consists of peripheral lesions, found in centriacinar regions close to terminal and respiratory bronchioles, that arise from bronchioloalveolar epithelium.
The vast majority of exposed rats had little or no evidence of lung neutrophilia and centriacinar fibrosis (Finch et al.
Long-term exposure to ozone increases acute pulmonary centriacinar injury by 1-nitronaphthalene: I.
This conclusion is consistent with the time relationship of administration of TMP-SMZ and the clinical course, as well as with the transaminase increase and the histologic picture of massive centriacinar necrosis.
Centriacinar (CAR) disease in the lungs of young adults: a preliminary report.
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