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central pontine myelinolysis

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central pontine myelinolysis
Neuropathology A condition characterized by softening of the base of the brain at the pons with damage to the myelin sheath, related to aggressive correction of hyponatremia; first identified in alcoholics–Wernicke-Korsakoff syndrome, CPM also occurs in AIDS, infection, lymphoproliferative disorders–eg, AML, malnutrition, and venous obstruction Clinical Weakness, double vision, muscle spasms, speech defects, delirium, sleep disorders, hallucinations, tremors and uncontrolled eye movements Imaging Defects are seen by MRI Prevention Slow correction of electrolytic imbalance


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Glynis suffers from central pontine myelinolysis, which affects her vision and movement and she is registered as partially disabled.
Osmotic demyelination, or central pontine myelinolysis, in association with the rapid correction of an acute hyponatremia (ie, <48 hour duration), has not been reported (86) and should never be an impediment to rapidly correcting hyponatremia in symptomatic EAH (7,21-23,26,43,46,54,60).
Wernicke's encephalopathy and central pontine myelinolysis associated with hyperemesis gravidarum.
 
 
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