central pontine myelinolysis


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cen·tral pon·tine my·e·li·nol·y·sis

a sporadic disorder characterized by a localized area of demyelination in the center of the basis pontis that, on cross section, can vary substantially in size from one patient to another. In most instances, occurs concurrently with some other serious medical disorder (for example, chronic alcoholism, severe burns, advanced lymphomas); clinically may be asymptomatic or markedly symptomatic, depending on the size of the lesion.

central pontine myelinolysis

A condition characterised by softening of the base of the brain at the pons with damage to the myelin sheath, related to aggressive correction of hyponatraemia. First identified in alcoholics (Wernicke-Korsakoff syndrome), CPM also occurs in AIDS, infection, lymphoproliferative disorders (e.g., AML), malnutrition, and post-stem cell transplantation venous obstruction.
 
Clinical findings
Weakness, double vision, muscle spasms, speech defects, delirium, sleep disorders, hallucinations, tremors and uncontrolled eye movements.
 
Imaging
Defects by MRI.

Prevention
Slow correction of electrolytic imbalance.

central pontine myelinolysis

Neuropathology A condition characterized by softening of the base of the brain at the pons with damage to the myelin sheath, related to aggressive correction of hyponatremia; first identified in alcoholics–Wernicke-Korsakoff syndrome, CPM also occurs in AIDS, infection, lymphoproliferative disorders–eg, AML, malnutrition, and venous obstruction Clinical Weakness, double vision, muscle spasms, speech defects, delirium, sleep disorders, hallucinations, tremors and uncontrolled eye movements Imaging Defects are seen by MRI Prevention Slow correction of electrolytic imbalance.

central pontine myelinolysis

A rare disorder featuring an area of severe loss of myelin in nerve fibres running through the middle of the PONS in the brainstem. There is progressive failure of verbal articulation (dysarthria) and spastic paralysis in all four limbs (quadriplegia). The condition may occur in alcoholism, liver disease, kidney failure and rapid correction of severe sodium depletion.
References in periodicals archive ?
Zolpidem dramatically improved motor and speech function in a patient with central pontine myelinolysis.
Treatment of central pontine myelinolysis with therapeutic plasmapheresis.
A drawback to using HTS in the resuscitation phase is that clinicians need to know the patient's serum sodium levels before initiating HTS therapy If the initial serum sodium level is 130 mmol/L or lower, a rapid increase could cause central pontine myelinolysis, a devastating complication.
If too rapid correction of serum sodium occurs, the patient is placed at risk for developing central pontine myelinolysis (Braunwald et al.

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