central nervous system (CNS) effects of local anaesthetics (LAs)

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central nervous system (CNS) effects of local anaesthetics (LAs)

relative or actual toxic (overdose) levels of local anaesthetics include initial excitement, euphoria and talkativeness, numbness of the tongue and perioral tissues, light-headedness, dizziness, tinnitus and difficulty with visual focus, progressing to slurring of speech, shivering, facial/hand/foot twitches, drowsiness and fleeting unconsciousness, to generalized tonic/clonic convulsions, respiratory depression and ultimately death; toxic effects are dose-dependent
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