central giant cell granuloma


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central giant cell granuloma

An osteodestructive lesion of uncertain pathogenesis, which most commonly occurs in the young female mandible, and is more lytic than peripheral giant cell granuloma.

Imaging
Radiolucent destructive lesion with faint trabeculation and loculation.
 
DiffDx
Giant cell bone tumour, PTH-induced “brown” tumour (hyperparathyroidism).
 
Management
Curettage.
References in periodicals archive ?
Central giant cell granuloma of the jaws: a clinical, radiologic and histopathologic study of 26 cases.
Calcitonin treatment for central giant cell granulomas of the mandible: Report of two cases.
Central giant cell granulomas (arising from within the bonel are generally associated with hyperparathyroidism, whereas peripheral giant cell granulomas arising from or near the surface of the bone apparently are not associated with hyperparathyroidism (7); however it is advisable to test for hyperparathyroidism in the latter condition, if multiple lesions occur.
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