cellular immunodeficiency

cellular immunodeficiency

n.
Any of a group of disorders associated with recurrent bacterial, fungal, protozoal, and viral infections and characterized by atrophy of the thymus gland, depressed cell-mediated immunity, and defective humoral immunity. Also called Nezelof type of thymic alymphoplasia.
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To the Editor: Mycobacterium shigaense is a novel, slow-growing, scotochromogenic mycobacterium (1), initially reported in 2012 as an opportunistic pathogen isolated from skin biopsy samples from a patient with a history of Hodgkin disease and severe cellular immunodeficiency.
a novel slowly growing scotochromogenic mycobacterium that produced nodules in an erythroderma patient with severe cellular immunodeficiency and a history of Hodgkin's disease.
The mechanisms of susceptibility for TB in HD patients are, however, not completely known, but a complex cellular immunodeficiency has been attributed to HD.
It appears almost exclusively among people with cellular immunodeficiency, and it can occur with revaccination of people who have become immunosuppressed since their primary vaccination.
Although severe cellular immunodeficiency can often facilitate the development of many infections, only 4 clinical cases of TB in patients undergoing HCV antiviral therapy have been described in the literature (6-8), and only 1 of these was clearly described as a TB reactivation (7).
Pecher and Funchs suggested that patients with lacaziosis have a cellular immunodeficiency (5).
However, since Jorge Lobo disease is restricted to specific areas of the world and the number of AIDS cases is increasing, especially in Latin America, a possible correlation between HIV infection and Jorge Lobo disease should be considered because of the associated cellular immunodeficiency.

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