cellular angiofibroma

cellular angiofibroma

A benign mesenchymal tumour of older (age 40 to 60) women composed of a highly cellular spindle cell component and prominent stromal blood vessels.

Vulvovaginal, inguinoscrotal regions; less commonly retroperitoneum, perineum and subcutaneous tissues of chest. Similar lesions in men are called angiomyofibroblastoma-like tumours.

DiffDx B
artholin gland cyst.

Local excision with clear margins.
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References in periodicals archive ?
Fibroepithelial stromal polyp, superficial angiomyxoma, angiomyofibroblastoma, cellular angiofibroma and smooth muscle tumours also need to be considered in the differential diagnoses of a polypoidal mass in the perineum.
These entities include benign lesions such as sclerotic fibroma, (2) cellular angiofibroma, (3) giant cell angiofibroma, (4) solitary fibrous tumor, (5) medallion-like dendrocyte hamartoma (plaquelike [CD34.
Spindle Cell Neoplasms and Their Differential Diagnoses Fibrohistiocytic and fibroblastic neoplasm Dermatofibrosarcoma protuberans and giant cell fibroblastoma Myxoinflammatory fibroblastic sarcoma Solitary fibrous tumor Giant cell angiofibroma Lipofibromatosis Fibroma Superficial angiomyxoma Superficial acral fibromyxoma Cellular digital fibroma Cellular angiofibroma Superficial [CD34.
Microscopically, cellular angiofibroma demonstrates short stubby nuclei, wispy collagen,numerous (hyalinized) vessels and is stained for CD34 +/-, desmin -/+, SMA -/+ and molecular identification is RB1 deletion.
Cellular angiofibroma was first described by Nucci et al.
Based on morphological and immunohistochemical features, a diagnosis of cellular angiofibroma was made.
Cellular angiofibroma is a rare benign tumour originating from the superficial soft tissues of the genital area (2).
Clinically and morphologically, cellular angiofibroma can simulate other benign tumours like leiomyoma, angiomyofibroblastoma, spindle cell lipoma and perineurioma (1, 5).
Solitary fibrous tumour is characterized by areas with the staghorn vascular pattern and dense collagenous stroma in contrast to hyalinized round vessels and wispy collagen of cellular angiofibroma.
Cellular angiofibroma and related fibromatous lesions of the vulva: report of a series of cases with a morphological spectrum wider than previously described.
Cellular angiofibroma with atypia or sarcomatous transformation: Clinicopathologic analysis of 13 cases.
Cellular angiofibroma of oral mucosa: report of two cases.

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