cell-mediated immunity

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Related to cell-mediated immunity: humoral immunity, cellular immunity, cellular immune response, Adaptive immunity

cell-·me·di·at·ed im·mu·ni·ty (CMI),

, cellular immunity
Immune responses mediated by activated, antigen-specific T lymphocytes. These T cells may function as effector cells or may orchestrate propagation of the inflammatory response and cellular recruitment through their secretion of cytokines and chemokines.
Synonym(s): delayed hypersensitivity (1)

cell-mediated immunity

Immunity resulting from a cell-mediated immune response. Also called cellular immunity.

cell-mediated immunity

cell-me·di·at·ed im·mu·ni·ty

, cellular immunity (CMI) (sel'mē'dē-āt-ĕd i-myū'ni-tē, sel'yū-lăr)
Immune responses that are initiated by T lymphocytes and mediated by T lymphocytes, macrophages, or both (e.g., graft rejection, delayed-type hypersensitivity).
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cell-mediated immunity

Abbreviation: CMI.
The regulatory and cytotoxic activities of T cells during the specific immune response. This process requires about 36 hr to reach its full effect. Synonym: T-cell–mediated immunity See: illustration; humoral immunity

Unlike B cells, T cells cannot recognize foreign antigens on their own. Foreign antigens are recognized by antigen-presenting cells (APCs) such as macrophages, which engulf them and display part of the antigens on the APC's surface next to a histocompatibility or “self-” antigen (macrophage processing). The presence of these two markers, plus the cytokine interleukin-1 (IL-1) secreted by the APCs activates CD4 helper T cells (TH cells), which regulate the activities of other cells involved in the immune response.

CMI includes direct lysis of target cells by cytotoxic T cells, creation of memory cells that trigger a rapid response when a foreign antigen is encountered for the second time, and delayed hypersensitivity to tissue and organ transplants. T cells also stimulate the activity of macrophages, B cells, and natural killer cells. These functions are controlled largely by the secretion of lymphokines such as the interleukins, interferons, and colony-stimulating factors. Lymphokines facilitate communication and proliferation of the cells in the immune system.

See also: immunity

cell-mediated immunity

Action by the immune system involving T cells (T LYMPHOCYTES) and concerned with protection against viruses, fungi, TUBERCULOSIS and cancers and rejection of foreign grafted material. Cell-mediated immunity is not primarily effected by ANTIBODIES.


effected by cellular rather than chemical elements.

cell-mediated hypersensitivity
see delayed hypersensitivity.
cell-mediated immunity
see cellular immunity.
cell-mediated lympholysis assay
a test of cell-mediated immunity in which activated cytoxic T lymphocytes cause lysis of 51Cr-labeled target cells.
References in periodicals archive ?
Cell-mediated immunity, Epstein-Barr virus and nasopharyngeal carcinoma.
This apparent anomaly in the immunotoxic impact of PRN exposure on different immune compartments prompted us to consider whether the effects of PRN on cell-mediated immunity might be more subtle or less easily detectable than effects on other immune compartments.
Emphasis on cell-mediated immunity versus humoral immunity changes according to the type of T-helper lymphocytes responding to an infectious threat.
Partial defects of cell-mediated immunity in patients with epidermodysplasia verruciformis.
Cell-mediated immunity after measles in Guinea-Bissau: historical cohort study.
They include local ischemia secondary to vasoconstriction, chemical irritation from adulterants put in "cut" cocaine, and infection secondary to trauma, decreased humoral and cell-mediated immunity, and impaired mucociliary transport:
Further studies in inbred chickens established that the cross-protection was due to cell-mediated immunity and that it could be transferred by CD8+ T cells but not by antibodies (29).
Investigators suspect that rhIL-12 enhances cell-mediated immunity by inducing interferon-[gamma] production and by augmenting natural killer cell cytotoxicity and cytotoxic T-cell proliferation and function.
DEPs may also suppress cell-mediated immunity by inhibiting ANJ secretion of IL-12, a key cytokine for the initiation of T helper type 1 cell development in Listeria infection.
The etiologic factors that cause sinonasal polyposis are still unclear, but there is evidence that cell-mediated immunity might play a role in its pathogenesis.
Some researchers worry that exaggerated cell-mediated immunity could develop into autoimmune disease, in which the immune system attacks the body's own tissues.
Current approaches to vaccine design: neutralizing antibodies, cell-mediated immunity.

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