cell-mediated immune response


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Related to cell-mediated immune response: cellular immunity, humoral immune response

cell-mediated immune response

(sĕl′mē′dē-ā′tĭd)
n.
The immune response produced when sensitized T cells directly attack foreign antigens and secrete lymphokines that initiate the body's humoral immune response. Also called cellular immune response.

cell-mediated immune response

a delayed reaction of the immune system, mediated primarily by sensitized T lymphocytes rather than antibodies. Cell-mediated immune response reactions are responsible for defense against certain bacterial, fungal, and viral pathogens; malignant cells; and other foreign proteins and tissues. Allergic dermatitis is an example of a cell-mediated immune response. Also called cellular hypersensitivity reaction, delayed hypersensitivity reaction, type IV hypersensitivity. Compare anaphylactic hypersensitivity.
References in periodicals archive ?
Activation of cutaneous immunity by percutaneous absorption of chemical through the stratum corneum is well established; however, given the long dissolution half-life for beryllium metal and its alloys, we hypothesized that beryllium particles would have to colocalize with the cutaneous antigen-presenting cell in the epidermis in order to activate a cell-mediated immune response.
Our results will impact multiple physiological and pathological situations involving T cell-mediated immune responses.
Cell-mediated immune responses to antigens of Bordetella pertussis and protection against pertussis in school children.
When combined with disease-specific antigens, the technology creates JuvaVax vaccines capable of activating substantial antibody- and cell-mediated immune responses, particularly induction of cytotoxic T lymphocytes.
When combined with disease-specific antigens, the technology creates JuvaVax(TM) vaccines capable of activating substantial antibody- and cell-mediated immune responses, particularly induction of cytotoxic T lymphocytes.
The essential components of humoral and cell-mediated immune responses associated with protection must be identified before prophylactic vaccine trials against any pathogen are implemented.