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cell-mediated cytotoxicity

   Also found in: Dictionary/thesaurus, Wikipedia 0.02 sec.
cytotoxicity /cy·to·tox·ic·i·ty/ (si″to-tok-sis´ĭ-te) the degree to which an agent possesses a specific destructive action on certain cells or the possession of such action.cy´totoxic
antibody-dependent cell-mediated cytotoxicity  (ADCC) lysis of antibody-coated target cells by effector cells with cytolytic activity and Fc receptors.
cell-mediated cytotoxicity  cytolysis of a target cell by effector lymphocytes, such as cytotoxic T lymphocytes or NK cells; it may be antibody-dependent or independent.
cell-mediated cytotoxicity,
cytolysis of a target cell by effector lymphocytes, such as cytotoxic T lymphocytes or natural killer cells. It may be antibody-dependent (antibody-dependent cell-mediated cytotoxicity) or independent, as in certain type IV hypersensitivity reactions.


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The resulting product is expected to have target specificity similar to Rituximab (Rituxan([R]), Mabthera([R])) and to have relatively higher antibody dependent cell-mediated cytotoxicity, or ADCC.
GTC Biotherapeutics and LFB Biotechnologies Developing CD20 Antibody by Business Wire
Role of antibody-dependent cell-mediated cytotoxicity in the efficacy of therapeutic anti-cancer monoclonal antibodies.
Clinical Data Suggest ERBITUX(R) Recruits the Body's Immune System to ... by Business Wire
nbsp;of the antibody has been shown in previous studies to be responsible for mediating antibody-dependent cell-mediated cytotoxicity and has been the target of Xencor's XmAb technology.
Xencor Data Published in PNAS Show Engineering the ''Fc'' Region of ... by Business Wire
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