Cell-death pathway | definition of cell-death pathway by Medical dictionary
death pathway (redirected from cell-death pathway)
finding that characterizes a protein that initiates final stage of cell death known as apoptosis. Mammalian families of proteins that execute the apoptotic pathway are Bcl-2, Apaf-1, and caspase-3. FAS receptor-ligand system is a regulator of apoptotic cell death.
References in periodicals archive
Cell-to-cell transmission of HIV is absolutely required for activation of the pathogenic HIV cell-death pathway
If PKR indeed detects long double-stranded RNA within a cell, the protein triggers a cell-death pathway
to eliminate the cell.
Antisense oligonucleotides were shown to be effective in vitro for targeting molecules in the cell-death pathway
The anthrax lethal toxin (LT) activates host proteins that go on to trigger the apoptotic or cell-death pathway
in cells that are infected.
When over-expressed in cancer cells, Bcl-2 proteins stop apoptosis by blocking Bax and Bak, two key elements of the cell-death pathway