death pathway

(redirected from cell-death pathway)

death pathway

finding that characterizes a protein that initiates final stage of cell death known as apoptosis. Mammalian families of proteins that execute the apoptotic pathway are Bcl-2, Apaf-1, and caspase-3. FAS receptor-ligand system is a regulator of apoptotic cell death.
Synonym(s): cell-death pathway
References in periodicals archive ?
Cell-to-cell transmission of HIV is absolutely required for activation of the pathogenic HIV cell-death pathway.
If PKR indeed detects long double-stranded RNA within a cell, the protein triggers a cell-death pathway to eliminate the cell.
Antisense oligonucleotides were shown to be effective in vitro for targeting molecules in the cell-death pathway (e.
The anthrax lethal toxin (LT) activates host proteins that go on to trigger the apoptotic or cell-death pathway in cells that are infected.
When over-expressed in cancer cells, Bcl-2 proteins stop apoptosis by blocking Bax and Bak, two key elements of the cell-death pathway.