Critical role for SV40 small-t antigen in human cell transformation
There is no increased intensity of HtrA2/Omi in 2 cases of SLL/CLL with either prolymphocytic or large cell transformation
(Figure 2, D).
By a still unidentified mechanism, cancer cell transformation
activates the ISG15 pathway.
Previous studies have shown that arsenic exposure can activate Akt, Erkl/2, p38, and JNK pathways and that Akt and Erkl/2 activation plays important roles in arsenic-induced cell transformation
(Eblin et al.
The large cell transformation
is characterized by biastic appearance of some of the cells of the chronic lymphocytic leukemia component, which demonstrate typical morphologic structure and immunohistochemical characteristics of RS cells, raising the possibility of HD.
Galectin-1 and Galectin-3 can interact with oncogenic Ras and mediate cell transformation
induced by this oncogene.
Keryx is developing KRX-0401 (perifosine), a novel, potentially first-in-class, oral anti-cancer agent that inhibits the phosphoinositide 3-kinase (PI3K)/Akt pathway, a key signaling cascade that has been shown to induce cell growth and cell transformation
A key early event in estrogen-dependent breast cancers is activation of ER-[alpha], which can occur with MCF-10A cell transformation
(Zhang et al.
Proto-oncogene amplification and overexpression in cadmium-induced cell transformation
With improved cell transformation
tools in hand, it has now become possible for scientists to investigate the physiological effects of drugs in various cell types.
Thus, there is a correlation between elevated levels of active phospho-MAPK and arsenic-induced prostate cell transformation
SGN-30 (anti-CD30 mAb) is Active and Well Tolerated in Patients with Cutaneous Anaplastic Large Cell Lymphoma, Large Cell Transformation
of Mycosis Fungoides and Lymphomatoid Papulosis (Abstract #268)