GJA8

(redirected from cell surface glycoprotein)

GJA8

A gene on chromosome 1q21.1 that encodes a calcium and pH-dependent transmembrane connexin protein required for lens growth and maturation of lens-fibre cells. 

Molecular pathology
GJA8 mutations have been linked to zonular pulverulent cataracts, nuclear progressive cataracts, and cataract-microcornea syndrome.
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The immunoreactivity of the tumor cells for vimentin and O13 antibody (also known as the Ewing/ PNET antigen) offers additional support for a diagnosis of EES and PNET O13 is a monoclonal antibody to a cell surface glycoprotein (p30/[32.
2) The immunohistochemical profile of ES includes strong reactivity to the cell surface glycoprotein CD99 antigen, encoded by the pseudoautosomal MIC-2 gene.
CS1 is a cell surface glycoprotein that is widely expressed on multiple myeloma cells but is minimally expressed on normal cells.
EpCAM is a cell surface glycoprotein present in normal epithelial cells and over-expressed in the majority of epithelial cancers.
EpCAM is a cell surface glycoprotein present in normal epithelia cells and over-expressed in the majority of epithelial cancers; these cancers account for approximately 70% of all cancers.
1,204,683, entitled "Ovarian cancer cells and myeloma cell surface glycoproteins, antibodies thereto, and uses therof," covers aspects of the Company's monoclonal antibody ICT-69, which targets human multiple myeloma and ovarian cancer cells.
About FcGRs: Fc gamma receptors are cell surface glycoproteins found on immune effector cells such as NK-cells (natural killer cells), macrophages, and neutrophils.
About FcGRs: Fc gamma receptors are cell surface glycoproteins found on macrophages, neutrophils, phagocytes, kidney mesangial cells, etc.