GJA8

(redirected from cell surface glycoprotein)

GJA8

A gene on chromosome 1q21.1 that encodes a calcium and pH-dependent transmembrane connexin protein required for lens growth and maturation of lens-fibre cells. 

Molecular pathology
GJA8 mutations have been linked to zonular pulverulent cataracts, nuclear progressive cataracts, and cataract-microcornea syndrome.
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Amatuximab (MORAb-009) is an investigational chimeric IgG1 antibody that targets a cell surface glycoprotein, mesothelin, which is over-expressed in a number of cancers.
The immunoreactivity of the tumor cells for vimentin and O13 antibody (also known as the Ewing/ PNET antigen) offers additional support for a diagnosis of EES and PNET O13 is a monoclonal antibody to a cell surface glycoprotein (p30/[32.
Mesothelin is a glycosylphosphatidylinositol-linked cell surface glycoprotein present on normal mesothelial cells that is overexpressed in numerous cancers including mesothelioma, ovarian and pancreatic cancer.
2) The immunohistochemical profile of ES includes strong reactivity to the cell surface glycoprotein CD99 antigen, encoded by the pseudoautosomal MIC-2 gene.
Thus far, two genes, the Alpha(subscript v) and Beta(subscript 3), which are found in the vitronectin receptor (a cell surface glycoprotein that promotes the spread of cells and often is found at sites of skin repair), appear to be involved in melanoma development.
CS1 is a cell surface glycoprotein that is widely expressed on multiple myeloma cells but is minimally expressed on normal cells.
EpCAM is a cell surface glycoprotein present in normal epithelial cells and over-expressed in the majority of epithelial cancers.
EpCAM is a cell surface glycoprotein present in normal epithelia cells and over-expressed in the majority of epithelial cancers; these cancers account for approximately 70% of all cancers.
1,204,683, entitled "Ovarian cancer cells and myeloma cell surface glycoproteins, antibodies thereto, and uses therof," covers aspects of the Company's monoclonal antibody ICT-69, which targets human multiple myeloma and ovarian cancer cells.
About FcGRs: Fc gamma receptors are cell surface glycoproteins found on immune effector cells such as NK-cells (natural killer cells), macrophages, and neutrophils.
About FcGRs: Fc gamma receptors are cell surface glycoproteins found on macrophages, neutrophils, phagocytes, kidney mesangial cells, etc.