cell receptor


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Related to cell receptor: B cell receptor

cell receptor

a protein located either on a cell's surface, in its cytoplasm, or in its nucleus that binds to a specific ligand (typically an ion or a molecule), initiating signal transduction and a change in cellular activity.

cell receptor

Any of the cell membrane proteins or intracellular proteins that react with chemicals, e.g., hormones, circulating in the cell's environment. The reaction triggers the cell's characteristic response to the hormone or other chemical.
See: drug receptor
See also: receptor
References in periodicals archive ?
Immunocore's ImmTACs, a new class of drug with ultra-high affinity for intracellular cancer targets, are synthetic, soluble T cell receptors (TCRs) that recognise diseased cells containing disease specific targets.
So the use of multiple, engineered T cell receptors may be one way to adjust for the higher potential for HIV mutation in humans.
These T Cell Receptor mimics (TCRm) offer valuable insight into how the immune system interacts with a diseased cell, yielding better immunology research, better clinical diagnostics, and better therapies such as monoclonal antibodies and vaccines.
Unlike classical treatments for MRSA, ImmuVen's T cell receptor proteins work by targeting the toxins rather than destroying the foreign organism.
Based on technology developed by the visionary George Church at Harvard Medical School, our technology allows for the identification of complete, natively paired B cell antibodies and T cell receptors across millions of single cells simultaneously at unprecedented resolution.
B Cell Receptor signaling contributes to the proliferation and survival of many B cell malignancies.
T Cell Receptors naturally recognise diseased cells and Immunocore's competitive advantage is its ability to engineer high affinity T Cell Receptors and link them to an antibody fragment which can activate the immune system to kill the targeted cancer or viral cells.
Amitabha Chattopadhyay and colleagues showed using lab tests, that long-term use of the drug caused significant changes in the structure and function of serotonin cell receptors.
Leveraging the scientific expertise between the two organizations, Lilly and BioNTech will collaborate to identify and validate novel tumor targets and their corresponding T cell receptors (TCRs) in one or more types of cancer.
Methods of the invention involve analyzing, changing, or modifying one or more amino acids in the junction region of a fusion protein in order to identify a T-cell epitope and reduce its ability to interact with a T cell receptor.
As another embodiment, T cell receptor mutants can be isolated by this method that are efficiently displayed on the yeast cell surface, providing a means of altering T cell receptor binding affinity and specificity by library screening.
New York Society for the Relief of the Ruptured and Crippled (New York, NY) has patented four unique transcripts isolated from the beta chain of the T cell receptor in T cells in the synovial tissue of a patient with rheumatoid arthritis.