Scientists were able to use this to prevent
cell death in living organisms.
The cytotoxic potential of arsenic trioxide leads to decreased mitochondrial membrane potential, fragmented DNA, and finally to apoptotic
cell death.
As no component of WNV had been previously implicated in in vivo
cell death of neuronal tissue, we reasoned that the WNV-Cp was a possible candidate, and we sought to investigate the effects of WNV-Cp in the brain in vivo.
There are 2 basic approaches to enhancing viability by inhibiting
cell death: the cells may be engineered to stably express proteins such as Bcl-2 which thwart entry into apoptosis, or small molecule protease inhibitors may be added to the bioreactor to inhibit the key effectors of the
cell death process.
The early discovery of the Bcl2 proto-oncogene and its subsequent linkage to apoptosis inhibition in human [Beta] cell lymphoma has led to the discovery of a number of additional structural homologs of Bcl-2 some of which function as apoptosis inducers subsequent to various
cell death signals.
In the study, xCELLigence System's recording of CI values allowed monitoring of primary cortical neuronal culture conditions, including plating, removal of glial cells, compound administration and
cell death profiling.
This is the one gene that regulates these two processes in cells, so now we can find targeted drugs to control the
cell death process," said Zhang.
When the mice were given antibodies that prevented transthyretin from interacting with the [beta]-amyloid protein, the mice showed typical brain
cell death.
Researchers have known for years that exposure to alcohol during the brain's growth spurt can ramp up
cell death in rats and people.
IDUN Pharmaceuticals was originally founded in 1993 and focused on the discovery and development of small molecule drugs that act by modulating the products of
cell death genes and on identifying new drug discovery targets within the
cell death pathway.
The UC Davis team and their collaborators at the National Institutes of Health and Johns Hopkins University report that Bax, a factor known to promote
cell death, is also involved in regulating the behavior of mitochondria, the structures that provide energy inside living cells.
The Laureates have identified key genes regulating organ development and programmed
cell death and have shown that corresponding genes exist in higher species, including man," declared the award statement released by the Nobel Assembly at the Karolinska Institute in Sweden.
