Scientists were able to use this to prevent cell death
in living organisms.
The cytotoxic potential of arsenic trioxide leads to decreased mitochondrial membrane potential, fragmented DNA, and finally to apoptotic cell death
As no component of WNV had been previously implicated in in vivo cell death
of neuronal tissue, we reasoned that the WNV-Cp was a possible candidate, and we sought to investigate the effects of WNV-Cp in the brain in vivo.
There are 2 basic approaches to enhancing viability by inhibiting cell death
: the cells may be engineered to stably express proteins such as Bcl-2 which thwart entry into apoptosis, or small molecule protease inhibitors may be added to the bioreactor to inhibit the key effectors of the cell death
The early discovery of the Bcl2 proto-oncogene and its subsequent linkage to apoptosis inhibition in human [Beta] cell lymphoma has led to the discovery of a number of additional structural homologs of Bcl-2 some of which function as apoptosis inducers subsequent to various cell death
In the study, xCELLigence System's recording of CI values allowed monitoring of primary cortical neuronal culture conditions, including plating, removal of glial cells, compound administration and cell death
This is the one gene that regulates these two processes in cells, so now we can find targeted drugs to control the cell death
process," said Zhang.
When the mice were given antibodies that prevented transthyretin from interacting with the [beta]-amyloid protein, the mice showed typical brain cell death
Researchers have known for years that exposure to alcohol during the brain's growth spurt can ramp up cell death
in rats and people.
IDUN Pharmaceuticals was originally founded in 1993 and focused on the discovery and development of small molecule drugs that act by modulating the products of cell death
genes and on identifying new drug discovery targets within the cell death
The UC Davis team and their collaborators at the National Institutes of Health and Johns Hopkins University report that Bax, a factor known to promote cell death
, is also involved in regulating the behavior of mitochondria, the structures that provide energy inside living cells.
The Laureates have identified key genes regulating organ development and programmed cell death
and have shown that corresponding genes exist in higher species, including man," declared the award statement released by the Nobel Assembly at the Karolinska Institute in Sweden.