cefuroxime axetil


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cefuroxime axetil

Apo-Cefuroxime, Ceftin, Ratio-Cefuroxime, Zinnat (UK)

cefuroxime sodium

Zinacef

Pharmacologic class: Second-generation cephalosporin

Therapeutic class: Anti-infective

Pregnancy risk category B

Action

Interferes with bacterial cell-wall synthesis and division by binding to cell wall, causing cell to die. Active against gram-negative and gram-positive bacteria, with expanded activity against gram-negative bacteria.

Exhibits minimal immunosuppressant activity.

Availability

Oral suspension: 125 mg/5 ml, 250 mg/5 ml

Powder for injection: 750 mg, 1.5 g, 7.5 g

Premixed containers: 750 mg/50 ml, 1.5 g/50 ml

Tablets: 125 mg, 250 mg, 500 mg

Indications and dosages

Moderate to severe infections, including those of skin, bone, joints, urinary or respiratory tract, gynecologic infections
Adults and children ages 12 and older: 750 mg to 1.5 g I.M. or I.V. q 8 hours for 5 to 10 days or 250 to 500 mg P.O. q 12 hours
Children ages 3 months to 12 years: 50 to 100 mg/kg/day I.V. or I.M. in divided doses q 6 to 8 hours

Gonorrhea
Adults: 750 mg to 1.5 g I.M. or I.V. as a single dose, or 1.5 g I.M. (750 mg in two separate sites), given with 1 g probenecid P.O.

Bacterial meningitis
Adults and children ages 12 and older: Up to 3 g I.V. or I.M. q 8 hours
Children ages 3 months to 12 years: 200 to 240 mg/kg I.V. daily in divided doses q 6 to 8 hours

Otitis media
Children ages 3 months to 12 years: 15 mg/kg P.O. q 12 hours (oral suspension) for 10 days, or 250 mg (tablets) P.O. q 12 hours for 10 days

Pharyngitis; tonsillitis
Adults and children ages 13 and older: 250 mg P.O. b.i.d. for 10 days
Children ages 3 months to 12 years: 125 mg P.O. q 12 hours for 10 days, or 20 mg/kg/day P.O. in two divided doses for 10 days as oral suspension (maximum 500 mg/day)

Dosage adjustment

• Renal impairment (for injectable formulation)

Contraindications

• Hypersensitivity to cephalosporins or penicillins

• Carnitine deficiency

Precautions

Use cautiously in:

• renal or hepatic impairment

• pregnant or breastfeeding patients

• children.

Administration

• Reconstitute drug in vial with sterile water for injection.

• Give by direct I.V. injection over 3 to 5 minutes into large vein or flowing I.V. line.

• For intermittent I.V. infusion, reconstitute drug with 100 ml of dextrose 5% in water or normal saline solution; administer over 15 minutes to 1 hour. For continuous infusion, give in 500 to 1,000 ml of compatible solution; infuse over 6 to 24 hours.

• Inject I.M. doses deep into large muscle mass.

• Give oral form with food.

• Be aware that tablets and oral suspension are exchangeable on a milligram-for-milligram basis.

Adverse reactions

CNS: headache, hyperactivity, hypertonia, seizures

GI: nausea, vomiting, diarrhea, abdominal pain, dyspepsia, pseudomembranous colitis

GU: hematuria, vaginal candidiasis, renal dysfunction, acute renal failure Hematologic: hemolytic anemia, aplastic anemia, hemorrhage

Hepatic: hepatic dysfunction Metabolic: hyperglycemia

Skin: toxic epidermal necrolysis, erythema multiforme, Stevens-Johnson syndrome

Other: allergic reaction, drug fever, superinfection, anaphylaxis

Interactions

Drug-drug. Antacids containing aluminum or magnesium, histamine2-receptor antagonists: increased cefuroxime absorption

Probenecid: decreased excretion and increased blood level of cefuroxime

Drug-diagnostic tests. Blood glucose, Coombs' test, urine glucose tests using Benedict's solution: false-positive results

Glucose, hematocrit: decreased levels

White blood cells in urine: increased level

Drug-food. Moderate- or high-fat meal: increased drug bioavailability

Patient monitoring

• Monitor patient for life-threatening adverse effects, including anaphylaxis, Stevens-Johnson syndrome, and pseudomembranous colitis.

• Monitor neurologic status, particularly for signs of impending seizures.

• Monitor kidney and liver function test results and intake and output.

• Monitor CBC with differential and prothrombin time; watch for signs and symptoms of blood dyscrasias.

• Monitor temperature; watch for signs and symptoms of superinfection.

Patient teaching

• Advise patient to immediately report rash or bleeding tendency.

• Instruct patient to take drug with food every 12 hours as prescribed.

• Teach patient how to recognize signs and symptoms of superinfection. Instruct him to report these right away.

• Advise patient to report CNS changes.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, and foods mentioned above.

cefuroxime axetil (sef´yōōrok´sēm ak´sətil),

n brand name: Ceftin;
drug class: second-generation cephalosporin;
action: inhibits bacterial cell wall synthesis, rendering cell wall osmotically unstable;
uses: eradication of gram-negative bacilli and gram-positive organisms; treatment of serious lower respiratory tract, urinary tract, skin, and gonococcal infections, septicemia, and meningitis.
References in periodicals archive ?
However, as shown in Table 2, in the case of the antibiotic cefuroxime axetil, there are cheaper varieties available in the branded market than the JAS price.
TABLE 1 Recommended antibiotic doses for adults and children with localized Lyme disease (10) * Antibiotic Dose in adults Dose in children Doxycycline 100 mg po bid 4 mg/kg/d in 2 doses (for children [greater than or equal to] 8 years) Amoxicillin 500 mg po tid 50 mg/kg/d in 3 doses Cefuroxime axetil 500 mg po bid 30 mg/kg/d in 2 doses ([dagger]) Azithromycin 500 mg po daily 10 mg/kg/d (max: 500 mg/d) ([double dagger]) for 7-10 days Clarithromycin 500 mg po bid 7.
Cefuroxime axetil is an old antibiotic, so patents claiming the drug and its methods of use are ineligible for Orange Book-listing.
Some evidence indicates that cefpodoxime 400 mg and cefuroxime axetil 1 g might be oral alternatives.
The most costly for 10day therapy include cefprozil, cefuroxime axetil, and cefpodoxine proxetil and cefixime (Mason, 1996; Pichichero, 1994).
hexahydrate,Amitriptyline,Atropine Sulphate,Azelac acid 20%,Betamethosone Ear drops,Bimatoprost,Broad spectrum suncreen SPF, BuprenorpChlorthalidone hine, Carvedilol, cefuroxime axetil Ceftazidime,
7,8,11) When treatment failures occur, the second choice of antibiotics includes amoxicillin-clavulanate, cefuroxime axetil or intramuscular ceftriaxone.
06%) Alternatives: amoxicillin-clavulanate lg bd plus additional 500 mg amoxicillin bd or 2 g bd SR for 10 days * Antihistamines Cefpodoxime proxetil 200 - 400 mg bd for 10 days * Mucolytics (guaifenesin) Cefuroxime axetil 500 mg - 1g bd for 10 days Children * Zinc preparations not Amoxicillin 90 mg/kg/d in 3 recommended (anosmia) divided doses for 10 days Alternatives: amoxicillin-clavulanate 90 mg/ kg/d total amoxicillin in 2 or 3 divided doses for 10 days Cefpodoxime proxetil 8 - 16 mg/kg/d bd for 10 days Cefuroxime axetil 15 - 30 mg/kg bd for 10 days (Please see reference 9 for [beta] -lactam allergy and failed initial therapy) 3.
In adults without neurologic involvement, this includes a 28day course of 100 mg doxycycline twice daily, 500 mg amoxicillin three times daily, or 500 mg cefuroxime axetil twice daily.
The most common comparison drugs were cefuroxime axetil (5 studies) and amoxicillin clavulanate (5 studies).