cefprozil


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cefprozil

 [sef-pro´zil]
a semisynthetic second-generation cephalosporinantibiotic with a wide range of antimicrobial activity, used in the treatment of otitis media and infections of the respiratory and oropharyngeal tracts, skin, and soft tissues; administered orally.

cefprozil

Apo-Cefprozil, Cefzil, Ran-Cefprozil, Sandoz Cefprozil

Pharmacologic class: Second-generation cephalosporin

Therapeutic class: Anti-infective

Pregnancy risk category B

Action

Interferes with bacterial cell-wall synthesis and division by binding to cell wall, causing cell to die. Active against gram-negative and gram-positive bacteria, with expanded activity against gram-negative bacteria. Exhibits minimal immunosuppressant activity.

Availability

Powder for suspension: 125 mg/5 ml, 250 mg/5 ml

Tablets: 250 mg, 500 mg

Indications and dosages

Uncomplicated skin infections caused by Staphylococcus aureus and Streptococcus pyogenes
Adults and children ages 13 and older: 250 to 500 mg P.O. q 12 hours or 500 mg P.O. daily for 10 days

Pharyngitis or tonsillitis caused by S. pyogenes
Adults and children ages 13 and older: 500 mg P.O. daily for at least 10 days

Acute bronchitis; acute bacterial chronic bronchitis caused by Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis
Adults and children ages 13 and older: 500 mg P.O. q 12 hours for 10 days

Acute sinusitis caused by S. pneumoniae, H. influenzae, and M. catarrhalis
Adults and children ages 13 and older: 250 mg P.O. q 12 hours for 10 days; for moderate to severe infections, 500 mg P.O. q 12 hours for 10 days
Children ages 6 months to 12 years: 7.5 mg/kg P.O. q 12 hours for 10 days; for moderate to severe infections, 15 mg/kg P.O. q 12 hours for 10 days

Otitis media caused by S. pneumoniae, H. influenzae, and M. catarrhalis
Children ages 6 months to 12 years: 15 mg/kg P.O. q 12 hours for 10 days

Dosage adjustment

• Renal impairment

Contraindications

• Hypersensitivity to cephalosporins or penicillins
• Renal failure

Precautions

Use cautiously in:
• renal or hepatic impairment
• pregnant or breastfeeding patients
• children.

Administration

• Obtain specimens for culture and sensitivity testing as necessary before starting therapy.
• Give drug with food.

Adverse reactions

CNS: headache, dizziness, drowsiness, hyperactivity, hypotonia, insomnia, confusion, seizures

GI: nausea, vomiting, diarrhea, abdominal pain, dyspepsia, pseudomembranous colitis

GU: hematuria, vaginal candidiasis, genital pruritus, renal dysfunction, toxic nephropathy

Hematologic: eosinophilia, aplastic anemia, hemolytic anemia, hemorrhage, bone marrow depression, hypoprothrombinemia

Hepatic: hepatic dysfunction

Skin: toxic epidermal necrolysis, diaper rash, erythema multiforme, Stevens-Johnson syndrome

Other: allergic reactions, carnitine deficiency, drug fever, superinfection, serum sickness-like reaction, anaphylaxis

Interactions

Drug-drug.Aminoglycosides: increased risk of nephrotoxicity

Antacids containing aluminum or magnesium, histamine2-receptor antagonists: increased cefprozil absorption

Probenecid: decreased excretion and increased blood level of cefprozil

Drug-diagnostic tests.Alanine aminotransferase, alkaline phosphatase, aspartate aminotransferase, bilirubin, blood urea nitrogen, creatinine, eosinophils, gamma-glutamyltransferase, lactate dehydrogenase, white blood cells in urine: increased levels

Blood glucose, Coombs' test, urine glucose tests using Benedict's solution: false-positive results

Platelets, white blood cells: decreased counts

Drug-food.Moderate- or high-fat meal: increased drug bioavailability

Patient monitoring

Stay alert for life-threatening reactions, including anaphylaxis, serum sickness-like reaction, Stevens-Johnson syndrome, and pseudomembranous colitis.
• Monitor neurologic status, particularly for signs and symptoms of impending seizures.
• Monitor kidney and liver function test results and assess fluid intake and output.
• Monitor CBC with white cell differential, prothrombin time, and bleeding time. Watch for signs and symptoms of blood dyscrasias, especially hypoprothrombinemia.
• Monitor temperature. Stay alert for signs and symptoms of superinfection.

Patient teaching

Advise patient to immediately report rash, bleeding tendency, or CNS changes.
• Teach patient to recognize signs and symptoms of superinfection, and instruct him to report these right away.
• Tell patient to take drug with food.
• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, and foods mentioned above.

cefprozil

/cef·pro·zil/ (sef-pro´zil) a broad-spectrum, second-generation cephalosporin effective against a wide range of gram-positive and gram-negative bacteria.

cefprozil

(sĕf-prō′zĭl)
n.
A broad-spectrum oral cephalosporin antibiotic used to treat respiratory and skin infections.
References in periodicals archive ?
Global Cefprozil Market research report spreads across 178 pages, profiling 15 Cefprozil companies and supported with 245 tables and figures is now available in the pharmaceuticals intelligence studies' collection of ReportsnReports.
Short-course therapy with several antibiotics including the cephalosporins (cefuroxime, cefprozil, cefpodoxime) has been shown to be non-inferior to a 10-day course of penicillin
2, Worcester, charged with possession of crack cocaine and possession of Cefprozil, continued to May 17.
The remainder of the patient's hospital course was unremarkable, and he was discharged home on postoperative day 9 on oral cefprozil and subcutaneous enoxaparin.
150 mg/kg/gun (7 -10 gun) Ceftriaxone 50-75 mg/kg/gun Tek doz Cefotaxim 200 mg/kg/gun 8 saatte bir Cefprozil 15-30 mg/kg/gun 12 saatte bir (7-10 gun) (maksimum 1 gr) Cefdinir 14 mg/kg/gun 12 saatte bir (7-10 gun) Cefpodoxime 14 mg/kg/gun 12 saatte bir proxetil (7-10 gun) (maksimum 400 mg/kg/gun) Azitromisin (oral) 10 mg/kg/gun Tek doz (3-5 gun) Claritromisin 15 mg/kg/gun 12 saatte bir (5-7 gun) (maksimum 1 gr/kg/gun) Eritromisin 40 mg/kg/gun 6 saatte bir (5-7 gun) Vancomisin 40-60 mg/kg/gun 6 saatte bir (7-10 gun) (14-21 gun s.
The first patient was a 23-month-old girl who was referred on March 6, 2006, to a tertiary hospital for bilateral otitis media that had not responded to amoxicillin or later to cefprozil.
The other cephalosporins--cefuroxime, cefprozil, and cefdinir--at equivalent doses may do just as well.
of Meets 1997 patients CMAJ guidelines (b) Azithromycin 1 1 Cefotaxime + ampicillin 2 0 Cefotaxime + clindamycin 1 0 Ceftriaxone 6 6 Ceftriaxone + amoxicillin 1 0 Ceftriaxone + azithromycin 1 1 Cefuroxime 18 18 Cefuroxime + amoxicillin 1 0 Cefuroxime + Azithromycin 12 12 Cefuroxime + clindamycin 1 0 Cefprozil 1 0 Cefprozil + azithromycin 1 0 Pediazole 1 0 Piperacillin/tazobactam + aztreonam 1 0 Total 48 38 Percentage 79 (a) CMAJ, Canadian Medical Association Journal.
Amoxicillin 01 Amoxicillin and Clavulanic Acid (Augmentin) 02 Azithromycin (Zithromax) 03 Cafaclor (Ceclor) 04 Cefixime (Suprax) 05 Cefpodoxime (Vantin) 06 Cefprozil (Cefzil) 07 Cetriaxone (Rocephin) 08 Clarithromycin (Biaxin) 09 Erythromycin and Sulfisoxazone (Pediazole) 10 Loracarbef (Lorabid) 11 Trimethoprim and Sulfamethoxazole (Bactrim, Septra) 12 Other 13 No Data 99
LONDON -- The key intermediate of cephem compounds, GCLE (CAS 104146-10-3) is extensively used in the synthesis of a raft of antibiotics such as Cefpodoxime Proxetil, Cefprozil, Cefdinir, etc.
Some drugs that have expired and have a generic form as of today include cefuroxime axetil, ceftazidime, and cefprozil.