cefpodoxime proxetil


Also found in: Wikipedia.

cefpodoxime proxetil

Orelox (UK), Vantin

Pharmacologic class: Third-generation cephalosporin

Therapeutic class: Anti-infective

Pregnancy risk category B

Action

Interferes with bacterial cell-wall synthesis and division by binding to cell wall, causing cell to die. Active against gram-negative and gram-positive bacteria, with expanded activity against gram-negative bacteria. Exhibits minimal immunosuppressant activity.

Availability

Oral suspension: 50 mg/5 ml, 100 mg/5 ml

Tablets: 100 mg, 200 mg

Indications and dosages

Acute community-acquired pneumonia caused by Haemophilus influenzae or Streptococcus pneumoniae
Adults and children ages 13 and older: 200 mg P.O. q 12 hours for 14 days

Acute bacterial or chronic bronchitis
Adults and children ages 13 and older: 200 mg P.O. q 12 hours for 10 days

Uncomplicated gonorrhea; rectal gonococcal infection caused by Neisseria gonorrhoeae
Adults: 200 mg P.O. as a single dose

Uncomplicated urinary tract infections caused by Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, and Staphylococcus saprophyticus
Adults: 100 mg P.O. q 12 hours for 7 days

Skin and soft-tissue infections caused by Staphylococcus aureus and Streptococcus pyogenes
Adults and children ages 13 and older: 400 mg P.O. q 12 hours for 7 to 14 days

Acute otitis media caused by H. influenzae, S. pneumoniae, and Moraxella catarrhalis
Children ages 5 months to 12 years: 5 mg/kg P.O. q 12 hours (maximum of 200 mg/dose) or 10 mg/kg q 24 hours (maximum of 400 mg/dose) for 10 days

Tonsillitis and pharyngitis caused by S. pyogenes
Adults and children ages 13 and older: 100 mg P.O. q 12 hours for 5 to 10 days
Children ages 2 months to 12 years: 5 mg/kg P.O. q 12 hours for 5 to 10 days

Dosage adjustment

• Renal impairment

Contraindications

• Hypersensitivity to cephalosporins or penicillins

Precautions

Use cautiously in:
• renal impairment, phenylketonuria
• history of GI disease
• elderly patients
• pregnant or breastfeeding patients
• children.

Administration

• Obtain specimens for culture and sensitivity testing as necessary before starting therapy.
• Give tablets with food to enhance absorption. Oral suspension may be given with or without food.
• Don't give antacids within 2 hours of cefpodoxime.

Adverse reactions

CNS: headache, lethargy, paresthesia, syncope, seizures

CV: hypotension, palpitations, chest pain, vasodilation

EENT: hearing loss

GI: nausea, vomiting, diarrhea, abdominal cramps, oral candidiasis, pseudomembranous colitis

GU: vaginal candidiasis, nephrotoxicity

Hematologic: lymphocytosis, eosinophilia, bleeding tendency, hemolytic anemia, hypoprothrombinemia, neutropenia, thrombocytopenia, agranulocytosis, bone marrow depression

Hepatic: hepatic failure, hepatomegaly

Musculoskeletal: arthralgia

Respiratory: dyspnea

Skin: urticaria, maculopapular or erythematous rash

Other: chills, fever, superinfection, anaphylaxis, serum sickness

Interactions

Drug-drug.Aminoglycosides, loop diuretics: increased risk of nephrotoxicity

Antacids: decreased cefpodoxime absorption

Probenecid: decreased excretion and increased blood level of cefpodoxime

Drug-diagnostic tests.Alanine aminotransferase, alkaline phosphatase, aspartate aminotransferase, bilirubin, blood urea nitrogen, creatinine, eosinophils, gamma-glutamyltransferase, lactate dehydrogenase: increased levels
Coombs' test, urinary 17-ketosteroids, nonenzyme-based urine glucose tests (such as Clinitest): false-positive results

Hemoglobin, platelets, white blood cells: decreased values

Drug-herbs.Angelica, anise, arnica, asafetida, bogbean, boldo, celery, chamomile, clove, danshen, fenugreek, feverfew, garlic, ginger, ginkgo, ginseng, horse chestnut, horseradish, licorice, meadowsweet, onion, papain, passionflower, poplar, prickly ash, quassia, red clover, turmeric, wild carrot, wild lettuce, willow: increased risk of bleeding

Patient monitoring

• Assess CBC and kidney and liver function test results.
• Monitor for signs and symptoms of superinfection and other serious adverse reactions.
• Be aware that cross-sensitivity to penicillins may occur.

Patient teaching

• Instruct patient to take drug with food or milk to reduce GI distress and enhance absorption.
• Advise patient not to take antacids within 2 hours of drug.
• Tell patient to continue to take full amount prescribed even when he feels better.
• Instruct patient to report signs and symptoms of allergic response and other adverse reactions, such as rash, easy bruising, bleeding, severe GI problems, or difficulty breathing.
• If patient is being treated for gonorrhea, instruct him to have partner tested and treated (as needed) and to use barrier contraception to prevent reinfection.
• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, and herbs mentioned above.

cefpodoxime proxetil

(sĕf′pə-dŏk′sēm′ prŏk′sə-tĭl)
n.
A broad-spectrum oral cephalosporin antibiotic.

cefpodoxime proxetil (sef´podok´-sēm prok´sətil),

n brand name: Vantin;
drug class: second-generation cephalosporin;
action: inhibits bacterial cell wall synthesis, rendering cell wall osmotically unstable;
uses: upper and lower respiratory tract infections, pharyngitis and tonsillitis, gonorrhea, urinary tract infections, skin structure infections.
References in periodicals archive ?
Putney launched two first-to-market FDA approved veterinary generics in 2013, Putney Enrofloxacin Tablets (generic of Baytril) and Putney Cefpodoxime Proxetil (generic of Simplicef).
06%) Alternatives: amoxicillin-clavulanate 1g bd plus additional 500 mg amoxicillin bd * Antihistamines or 2 g bd SR for 10 days * Mucolytics (guaifenesin) Cefpodoxime proxetil 200 - 400 mg bd for 10 days * Zinc preparations not Cefuroxime axetil 500 mg - 1g bd for 10 days Children Amoxicillin 90 mg/kg/d in 3 divided doses for 10 days Alternatives: amoxicillin-clavulanate 90 mg/kg/d total amoxicillin in 2 or 3 divided doses for 10 days Cefpodoxime proxetil 8 - 16 mg/kg/d bd for 10 days recommended (anosmia) Cefuroxime axetil 15 - 30 mg/kg bd for 10 days (Please see reference 9 for [beta]-l actam allergy and failed initial therapy) 3.
Figure 1 and 2) The patient was treated with cefpodoxime proxetil and methenamine anhydromethylene citrate.
Sodium alginate polymeric floating beads for the delivery of cefpodoxime proxetil (2009) Journal of Applied Polymer Science, 114 (3), pp.
Treatment of acute maxillary sinusitis--comparing cefpodoxime proxetil with amoxicillia.
The second choice is amoxicillin, the third is cefpodoxime proxetil, and the fourth is cefuroxime axetil.
LONDON -- The key intermediate of cephem compounds, GCLE (CAS 104146-10-3) is extensively used in the synthesis of a raft of antibiotics such as Cefpodoxime Proxetil, Cefprozil, Cefdinir, etc.
This is Putney's second major product launch of 2013, coming just two months after the company launched Putney Cefpodoxime Proxetil tablets, the first and only FDA approved veterinary generic of Simplicef.
06%) Alternatives: amoxicillin-clavulanate lg bd plus additional 500 mg amoxicillin bd or 2 g bd SR for 10 days * Antihistamines Cefpodoxime proxetil 200 - 400 mg bd for 10 days * Mucolytics (guaifenesin) Cefuroxime axetil 500 mg - 1g bd for 10 days Children * Zinc preparations not Amoxicillin 90 mg/kg/d in 3 recommended (anosmia) divided doses for 10 days Alternatives: amoxicillin-clavulanate 90 mg/ kg/d total amoxicillin in 2 or 3 divided doses for 10 days Cefpodoxime proxetil 8 - 16 mg/kg/d bd for 10 days Cefuroxime axetil 15 - 30 mg/kg bd for 10 days (Please see reference 9 for [beta] -lactam allergy and failed initial therapy) 3.
As a research-based developer, manufacturer and marketer, Sankyo has introduced to the international market several breakthrough drugs from its own research, including pravastatin (Mevalotin(TM) or Pravachol(TM)), an anti-hyperlipidemic agent; cefpodoxime proxetil (Banan(TM) or Vantin(TM)), an oral anti-infective agent; and loxoprofen sodium (Loxonin(TM)), the largest anti-inflammatory drug in Japan.
a rapidly growing pharmaceutical company focused on the development and sale of generic prescription medicines for pets, has launched generic veterinary Cefpodoxime Proxetil tablets.
As a research-based developer, manufacturer, and marketer, Sankyo has introduced to the international market several breakthrough drugs from its own research, including pravastatin (Mevalotin(TM) or Pravachol(TM)), an anti-hyperlipidemic agent; cefpodoxime proxetil (Banan(TM) or Vantin(TM)), an oral anti-infective agent; and loxoprofen sodium (Loxonin(TM)), the largest anti-inflammatory drug in Japan.